All Phenotypes Lmo2<tm2(cre)Thr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmo2^tm2(cre)Thr
targeted mutation 2, Terence H Rabbitts
MGI:2671438

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421774
cn2	Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Smim3^tm1Anjm/Smim3⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421776
cn3	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421779
cn4	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421780
cn5	Arsi^tm1Anjm/Arsi⁺ Csf1r^tm1Anjm/Csf1r⁺ Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421695
cn6	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421775
cn7	Lmo2^tm2(cre)Thr/Lmo2⁺ Kmt2a^tm1Thr/Kmt2a⁺ Mllt1^tm1Thr/Mllt1⁺	involves: 129S/SvEv	MGI:2671953

Allelic Composition	Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:155870 )

• decreased granulocyte/macrophage colony-forming units

abnormal megakaryocyte progenitor cell morphology ( J:155870 )

• megakaryocyte colony-forming units numbers of are depressed in the bone marrow

decreased erythrocyte cell number ( J:155870 )

• a reduction in the number of circulating RBCs

decreased hemoglobin content ( J:155870 )

increased mean corpuscular volume ( J:155870 )

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

thrombocytopenia ( J:155870 )

decreased monocyte cell number ( J:155870 )

• total monocyte numbers are lower in the blood

immune system

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

decreased monocyte cell number ( J:155870 )

• total monocyte numbers are lower in the blood

Allelic Composition	Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Smim3^tm1Anjm/Smim3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3^tm1Anjm mutation (0 available); any Smim3 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow

• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• a decrease in erythroid colony-forming units in the bone marrow

decreased erythrocyte cell number ( J:155870 )

• there are a reduced numbers of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton

abnormal bone marrow morphology ( J:155870 )

• bone marrow dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in bone marrow

• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• as measured by erythroid colony-forming units in bone marrow

decreased erythrocyte cell number ( J:155870 )

• a reduced number of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Arsi^tm1Anjm/Arsi⁺ Csf1r^tm1Anjm/Csf1r⁺ Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arsi^tm1Anjm mutation (0 available); any Arsi mutation (73 available)
Csf1r^tm1Anjm mutation (0 available); any Csf1r mutation (67 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• no substantial changes in RBC numbers or hemoglobin concentrations

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

macrocytic anemia ( J:155870 )

abnormal bone marrow cell number ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

decreased bone marrow cell number ( J:155870 )

• a reduced number of cells are flushed from the femurs

• histological bone marrow sections have mild to high hypocellularity

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• decreased granulocyte/macrophage colony-forming units

• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow

abnormal megakaryocyte morphology ( J:155870 )

• monolobulated megakaryocytes in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• a decreased number of erythroid colony-forming units

abnormal megakaryocyte progenitor cell morphology ( J:155870 )

• a decreased number of megakaryocyte colony-forming units

• considerably fewer in the bone marrow by flow cytometry

abnormal blood cell morphology ( J:155870 )

• pencil shaped cells are present in blood smears

abnormal common myeloid progenitor cell morphology ( J:155870 )

• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage

abnormal erythropoiesis ( J:155870 )

• prominent erythroid dysplasia, dyserythropoiesis

decreased erythrocyte cell number ( J:155870 )

decreased hemoglobin content ( J:155870 )

increased mean corpuscular volume ( J:155870 )

increased red blood cell distribution width ( J:155870 )

• increase in the mean red blood cell distribution width

macrocytosis ( J:155870 )

• in bone marrow and peripheral blood

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

abnormal mast cell morphology ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

thrombocytopenia ( J:155870 )

• modest

decreased monocyte cell number ( J:155870 )

• in the blood

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow

immune system

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

abnormal mast cell morphology ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

decreased monocyte cell number ( J:155870 )

• in the blood

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Lmo2^tm2(cre)Thr/Lmo2⁺ Kmt2a^tm1Thr/Kmt2a⁺ Mllt1^tm1Thr/Mllt1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Mllt1^tm1Thr mutation (0 available); any Mllt1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:84518 )

• 100% of mutants either die or are sacrified due to ill health by 120 days of age

neoplasm

increased hemolymphoid system tumor incidence ( J:100794 )

• all mice develop hematological malignancies

• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes

increased leukemia incidence ( J:84518 , J:100794 )

• develop myeloid leukemias as early as 1.5 months of age (J:84518)

• leukemic cells invade the spleen and into peripheral organs such as liver and kidneys with perivascular deposits of tumor cells in liver and in between glomerili of kidney (J:84518)

• mice have myelo-proliferative-like myeloid leukemia (J:100794)

hematopoietic system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

immune system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

liver/biliary system

pale liver ( J:84518 )

renal/urinary system

pale kidney ( J:84518 )

growth/size/body

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24