All Phenotypes Zfp423<nur12> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zfp423^nur12
neurological 12
MGI:2671784

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp423^nur12/Zfp423^nur12	involves: BALB/c * C57BL/6 * C3H	MGI:3693287
hm2	Zfp423^nur12/Zfp423^nur12	involves: C57BL/6J	MGI:3027223
ht3	Zfp423^nur12/Zfp423^Gt(XH542)Byg	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H	MGI:3693289

Allelic Composition	Zfp423^nur12/Zfp423^nur12
Genetic Background	involves: BALB/c * C57BL/6 * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp423^nur12 mutation (4 available); any Zfp423 mutation (274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ataxia and malformation in Zfp423^nur12/Zfp423^nur12 mice

behavior/neurological

tremors ( J:114758 )

ataxia ( J:114758 )

nervous system

dilated fourth ventricle ( J:114758 )

abnormal choroid plexus morphology ( J:114758 )

• reduced choroids plexus of the 4th ventricle

abnormal telencephalon morphology ( J:114758 )

dilated lateral ventricle ( J:114758 )

absent corpus callosum ( J:114758 )

abnormal hippocampus morphology ( J:114758 )

• reduced hippocampal formations

abnormal cerebellum morphology ( J:114758 )

• malformed

• pronounced anterior rotation of the cerebellum in the posterior fossa

• decreased cell proliferation in the germinal zones of the cerebellum

abnormal cerebellar cortex morphology ( J:114758 )

• Bergman glia fail to infiltrate the cerebellar cortex

• radial glial fibers found at lower densities than in controls

cerebellum vermis hypoplasia ( J:114758 )

• evident by E15.5

growth/size/body

decreased body weight ( J:114758 )

• P14 mutants show reduced weight gain

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
cerebellar disease	DOID:2786		J:114758
Dandy-Walker syndrome	DOID:2785	OMIM:220200	J:114758

Allelic Composition	Zfp423^nur12/Zfp423^nur12
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp423^nur12 mutation (4 available); any Zfp423 mutation (274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:85113 )

• animals do not live long past weaning

behavior/neurological

tremors ( J:85113 )

• described as a quivering when moving

ataxia ( J:85113 )

Allelic Composition	Zfp423^nur12/Zfp423^Gt(XH542)Byg
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp423^Gt(XH542)Byg mutation (0 available); any Zfp423 mutation (274 available)
Zfp423^nur12 mutation (4 available); any Zfp423 mutation (274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:114758 )

nervous system

cerebellum hypoplasia ( J:114758 )

• mild cerebellar hypoplasia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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