All Phenotypes Scn8a<nur14> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn8a^nur14
neurological 14
MGI:2671787

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn8a^nur14/Scn8a^nur14	C57BL/6J-Scn8a^nur14	MGI:3840662
hm2	Scn8a^nur14/Scn8a^nur14	involves: C57BL/6J	MGI:3027225
ht3	Scn8a^med-TgA4Bs/Scn8a^nur14	involves: C3H * C57BL/6J	MGI:3840663

Allelic Composition	Scn8a^nur14/Scn8a^nur14
Genetic Background	C57BL/6J-Scn8a^nur14

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^nur14 mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146758 )

• mice do not survive beyond 1 month of age

behavior/neurological

tremors ( J:146758 )

• pronounced

ataxia ( J:146758 )

• ataxic gait

hindlimb paralysis ( J:146758 )

• mice exhibit partial loss of hindlimb function by 2 weeks of age

Allelic Composition	Scn8a^nur14/Scn8a^nur14
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^nur14 mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:85113 )

• animals do not live to weaning age

behavior/neurological

hindlimb paralysis ( J:85113 )

Allelic Composition	Scn8a^med-TgA4Bs/Scn8a^nur14
Genetic Background	involves: C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-TgA4Bs mutation (0 available); any Scn8a mutation (99 available)
Scn8a^nur14 mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:146758 )

• mice do not survive beyond weaning

behavior/neurological

tremors ( J:146758 )

ataxia ( J:146758 )

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