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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mc4rGlu3
glucose3
MGI:2671841
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mc4rGlu3/Mc4rGlu3 C57BL/6J-Mc4rGlu3 MGI:3758177
ht2
Mc4rGlu3/Mc4r+ C57BL/6J-Mc4rGlu3 MGI:3758178
ht3
Mc4rGlu3/Mc4r+ involves: 129S6/SvEvTac MGI:3026692
ht4
Mc4rGlu3/Mc4r+ involves: C57BL/6J MGI:3026691


Genotype
MGI:3758177
hm1
Allelic
Composition
Mc4rGlu3/Mc4rGlu3
Genetic
Background
C57BL/6J-Mc4rGlu3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Obesity is observed in Mc4rGlu3/Mc4rGlu3 mice

growth/size/body
• at 12 weeks, male mice are lighter (34.1+/-0.6 g) compared to Mc4rm1Btlr homozygotes (38.8+/-1.0 g)
• at 20 weeks, male mice are lighter (43.0+/-0.7 g) compared to Mc4rm1Btlr homozygotes (48.8+/-0.3 g)
• at 8 weeks, male mice are significantly heavier (28.2+/-0.6 g) than heterozygotes (26.5+/-0.4 g) and wild-type mice (24.9+/-0.4 g)
• at 14 weeks, female mice are heavier (26.9+/-1.3 g) than heterozygous (22.9+/-0.6 g) and wild-type mice (21.8+/-0.8 g)

adipose tissue
• at 8 weeks, percent body fat in male mice is increased (14.3+/-1.5%) compared to in heterozygotes (9.6+/-0.8%) and wild-type mice (7.4+/-0.9%)
• at 20 weeks, percent body fat in male mice is increased (26.7+/-1.6%) compared to in heterozygotes (14.9+/-1.6%) and wild-type mice (10.0+/-2.6%)
• at 12 weeks, percent body fat in female mice is increased (15.6+/-1.5%) compared to in heterozygotes (10.6+/-1.0%) and wild-type mice (9.4+/-1.7%)
• at 20 weeks, percent body fat in female mice is increased (21.5+/-3.2%) compared to in heterozygotes (15.3+/-1.1%) and wild-type mice (9.0+/-1.9%)




Genotype
MGI:3758178
ht2
Allelic
Composition
Mc4rGlu3/Mc4r+
Genetic
Background
C57BL/6J-Mc4rGlu3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 8 weeks, male mice are larger (26.5+/-0.4 g) than wild-type mice (24.9+/-0.4 g)




Genotype
MGI:3026692
ht3
Allelic
Composition
Mc4rGlu3/Mc4r+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

homeostasis/metabolism




Genotype
MGI:3026691
ht4
Allelic
Composition
Mc4rGlu3/Mc4r+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

homeostasis/metabolism





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory