Phenotypes associated with this allele

• Allele Symbol: Erbb2^l11Jus8
• Allele Name: lethal, Chr 11, Justice 8
• Allele ID: MGI:2671879
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^l11Jus8/Erbb2^l11Jus8	129S5.B6(129S7)-Erbb2^l11Jus8	MGI:5661570
hm2	Erbb2^l11Jus8/Erbb2^l11Jus8	Not Specified	MGI:2673587

Genotype
MGI:5661570

hm1

• Allelic Composition: Erbb2^l11Jus8/Erbb2^l11Jus8
• Genetic Background: 129S5.B6(129S7)-Erbb2^l11Jus8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:222460 )

• mice die between E12.5 and E13

cardiovascular system

cardiovascular system phenotype ( J:222460 )

N • at E12.5, mice exhibit normal atrioventricular cushion development and outflow tract vessel septation

N • mice exhibit normal heart ventricle morphology and conduction

abnormal vitelline vasculature morphology ( J:222460 )

• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages

absent vitelline blood vessels ( J:222460 )

• by E12.5 in mice with thoracic hemorrhages

abnormal heart atrium morphology ( J:222460 )

• ubtle defects in atrial wall structure at E11.5

• at E11.5, 5 of 15 mice exhibit collapsing atria with reduced chamber lumen and thickening of irregularly folded myocardium

abnormal atrium myocardium morphology ( J:222460 )

• thickened and irregularly folded in 5 of 15 mice at E11.5

• myocardium detaches from the epi- and endocardium at E12.5

dilated heart atrium ( J:222460 )

• distended

hemorrhage ( J:222460 )

• severe head and thoracic hemorrhage

atrioventricular block ( J:222460 )

• partial atrioventricular block with partial or full atrial block

embryo

abnormal vitelline vasculature morphology ( J:222460 )

• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages

absent vitelline blood vessels ( J:222460 )

• by E12.5 in mice with thoracic hemorrhages

muscle

abnormal atrium myocardium morphology ( J:222460 )

• thickened and irregularly folded in 5 of 15 mice at E11.5

• myocardium detaches from the epi- and endocardium at E12.5

Genotype
MGI:2673587

hm2

• Allelic Composition: Erbb2^l11Jus8/Erbb2^l11Jus8
• Genetic Background: Not Specified

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:109155 )

• homozygous embryos die between 9.5 and 12.5 dpc

cardiovascular system

abnormal blood circulation ( J:85113 )

hemorrhage ( J:85113 )

• embryo hemorrhages

nervous system

kinked neural tube ( J:85113 )

• kinked neural tube

embryo

kinked neural tube ( J:85113 )

• kinked neural tube