mortality/aging
• mice die between E12.5 and E13
|
cardiovascular system
N |
• at E12.5, mice exhibit normal atrioventricular cushion development and outflow tract vessel septation
• mice exhibit normal heart ventricle morphology and conduction
|
• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages
|
• by E12.5 in mice with thoracic hemorrhages
|
• ubtle defects in atrial wall structure at E11.5
• at E11.5, 5 of 15 mice exhibit collapsing atria with reduced chamber lumen and thickening of irregularly folded myocardium
|
• thickened and irregularly folded in 5 of 15 mice at E11.5
• myocardium detaches from the epi- and endocardium at E12.5
|
• distended
|
hemorrhage
(
J:222460
)
• severe head and thoracic hemorrhage
|
• partial atrioventricular block with partial or full atrial block
|
embryo
• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages
|
• by E12.5 in mice with thoracic hemorrhages
|
muscle
• thickened and irregularly folded in 5 of 15 mice at E11.5
• myocardium detaches from the epi- and endocardium at E12.5
|