mortality/aging
• animals die after birth; 19% die between birth and weaning
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Allele Symbol Allele Name Allele ID |
l11Jus16 lethal, Chr 11, Justice 16 MGI:2671887 |
Summary |
2 genotypes |
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• animals die after birth; 19% die between birth and weaning
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit L-loop ventricles and situs inversus in the heart
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• in 3 of 17 mice
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• observed in 2 of 17 mutant mice
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• AVSD with dextrocardia is seen in 2 of 17 mice
• AVSD with levocardia is seen in 3 of 17 mice
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• mutant mice develop atrioventricular septal defects with complete penetrance and variable expressivity
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• 1 in 17 mice exhibit muscular ventricular septal defect
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• mutant mice exhibit situs inversus in the heart
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
atrioventricular septal defect | DOID:0050651 |
OMIM:606215 OMIM:614430 OMIM:614474 |
J:163196 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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