All Phenotypes Tg(Col2a1-cre)1Star MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Col2a1-cre)1Star
transgene insertion 1, Rene St-Arnaud
MGI:2671895

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ilk^tm1Star/Ilk^tm1Star Tg(Col2a1-cre)1Star/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2671930
cn2	Panx3^{tm1c(KOMP)Wtsi}/Panx3^{tm1c(KOMP)Wtsi} Tg(Col2a1-cre)1Star/0	involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N	MGI:5788534
cn3	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Col2a1-cre)1Star/0	involves: C57BL/6	MGI:4440962
cn4	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Col2a1-cre)1Star/0	involves: C57BL/6	MGI:4440960
cn5	Runx2^tm1.1Yyon/Runx2^tm1.1Yyon Tg(Col2a1-cre)1Star/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5570667

Allelic Composition	Ilk^tm1Star/Ilk^tm1Star Tg(Col2a1-cre)1Star/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilk^tm1Star mutation (1 available); any Ilk mutation (18 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

disproportionate dwarf ( J:84273 )

• newborn homozygotes were smaller than normal with the small size becoming more conspicuous with age

• forelimbs and hind limbs were shortened but not deformed

skeleton

abnormal skeleton development ( J:84273 )

chondrodystrophy ( J:84273 )

• moderate chondrodysplasia

• growth plate most affected in the proliferating zone

• Cyclin D1 expression reduced in the proliferating zone

• poor columnar organization

• chondrocytes more rounded

• chondrocyte differentiation unaffected

• apoptosis normal

Allelic Composition	Panx3^{tm1c(KOMP)Wtsi}/Panx3^{tm1c(KOMP)Wtsi} Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx3^{tm1c(KOMP)Wtsi} mutation (0 available); any Panx3 mutation (23 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased susceptibility to induced arthritis ( J:233542 )

• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis

osteophytes ( J:233542 )

• absent in a DMM surgery model of induced osteoarthritis

immune system

decreased susceptibility to induced arthritis ( J:233542 )

• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (34 available)
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:158761 )

• newborn mice are indistinguishable from Runx2^tm1Mjo homozygotes

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (34 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:158761 )

N	• mice exhibit normal skeletal morphology

Allelic Composition	Runx2^tm1.1Yyon/Runx2^tm1.1Yyon Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2^tm1.1Yyon mutation (0 available); any Runx2 mutation (44 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:210124 )

• due to difficulty breathing

skeleton

delayed bone ossification ( J:210124 )

• almost complete absence of mineralized tissue at E15.5

• however, ossification of the facial bone, skull bone and clavicle is normal

delayed endochondral bone ossification ( J:210124 )

• in newborn mice, including long bones and vertebrae

respiratory system

respiratory distress ( J:210124 )

• difficulty breathing at birth leading to death

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