Phenotypes associated with this allele

• Allele Symbol: Slc4a1^l11Jus51
• Allele Name: lethal, Chr 11, Justice 51
• Allele ID: MGI:2671922
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a1^l11Jus51/Slc4a1^l11Jus51	involves: C57BL/6J	MGI:2674088

Genotype
MGI:2674088

hm1

• Allelic Composition: Slc4a1^l11Jus51/Slc4a1^l11Jus51
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:85113 , J:109155 )

• most animals die within one week of birth (J:85113)

hematopoietic system

abnormal definitive hematopoiesis ( J:85113 )

anemia ( J:85113 )

• severe in juveniles; erythroid progenitor cells are present in normal numbers, suggesting anemia is due to loss of mature RBCs

macrocytic anemia ( J:85113 )

• noted in animals surviving to adulthood

abnormal erythrocyte morphology ( J:85113 )

abnormal erythrocyte cell number ( J:85113 )

• decreased red blood cell numbers

decreased erythrocyte cell number ( J:85113 )

decreased hematocrit ( J:85113 )

abnormal hemoglobin ( J:85113 )

• decreased hemoglobin

decreased hemoglobin content ( J:85113 )

increased nucleated erythrocyte cell number ( J:85113 )

• nucleated erythroid cells are found in circulation