Phenotypes associated with this allele

• Allele Symbol: Disp1^tm1Pab
• Allele Name: targeted mutation 1, Philip A Beachy
• Allele ID: MGI:2672101
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Disp1^tm1Pab/Disp1^tm1Pab	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2672102
cn2	Disp1^tm1Pab/Disp1^tm1Pab Shh^tm2Chg/Shh^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3687546

Genotype
MGI:2672102

hm1

• Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79457 )

• embryos die at or soon after E9.5

cardiovascular system

abnormal heart looping ( J:79457 )

• defective heart looping

distended pericardium ( J:79457 )

• at E9.5

embryo

abnormal first pharyngeal arch morphology ( J:79457 )

• mandibular component of the first branchial arch is severely reduced

fused first pharyngeal arch ( J:79457 )

• mandibular component is fused in the midline

abnormal embryo turning ( J:79457 )

• mutants exhibit a kink in the truck with dorsal instead of ventral curling of the tail, indicating that embryo turning is impaired

abnormal left-right axis patterning ( J:79457 )

• left/right asymmetry is disrupted as indicated by defective heart looping and disrupted asymmetric expression of Nodal in the left lateral plate mesoderm

decreased embryo size ( J:79457 )

• small at E9.5

abnormal neural fold formation ( J:79457 )

• midline fusion of the anterior lips of the cephalic neural plate and a poorly defined or absent midline groove

abnormal neural plate morphology ( J:79457 )

• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

abnormal neural tube morphology ( J:79457 )

• the ventral neural tube develops as an undifferentiated epithelial tube

abnormal somite development ( J:79457 )

• marker analysis indicates somite patterning defects

nervous system

abnormal neural plate morphology ( J:79457 )

• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

abnormal neural tube morphology ( J:79457 )

• the ventral neural tube develops as an undifferentiated epithelial tube

growth/size/body

decreased embryo size ( J:79457 )

• small at E9.5

vision/eye

abnormal optic vesicle formation ( J:79457 )

• incomplete separation of the bilateral evaginations that form the optic vesicles and by E8.5, the bilateral cup-like evaginations are replaced by a deep single evagination

craniofacial

abnormal first pharyngeal arch morphology ( J:79457 )

• mandibular component of the first branchial arch is severely reduced

fused first pharyngeal arch ( J:79457 )

• mandibular component is fused in the midline

Genotype
MGI:3687546

cn2

• Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab; Shh^tm2Chg/Shh⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

perinatal lethality, complete penetrance ( J:109101 )

• survive to at least E18.5

limbs/digits/tail

abnormal digit morphology ( J:109101 )

• digits show segmentation and calcification defects

preaxial polydactyly ( J:109101 )

• develop 6-7 digits per limb (preaxial polydactyly)