Phenotypes associated with this allele

• Allele Symbol: Smo^tm1.1Pab
• Allele Name: targeted mutation 1.1, Philip A Beachy
• Allele ID: MGI:2672132
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smo^tm1.1Pab/Smo^tm1.1Pab	Not Specified	MGI:3720038

Genotype
MGI:3720038

hm1

• Allelic Composition: Smo^tm1.1Pab/Smo^tm1.1Pab
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal first pharyngeal arch morphology ( J:79457 )

• mandibular component of the first branchial arch is severely reduced

fused first pharyngeal arch ( J:79457 )

• mandibular component of the first branchial arch is fused in the midline

abnormal developmental patterning ( J:79457 )

• at E9.5 mice have an abnormal trunk

abnormal embryo turning ( J:79457 )

• mutants exhibit a kink in the truck with dorsal instead of ventral curling of the tail, indicating defective embryonic turning

decreased embryo size ( J:79457 )

• small at E9.5

abnormal neural fold formation ( J:79457 )

• midline fusion of the anterior lips of the cephalic neural plate and a poorly defined or absent midline groove at E8.5

abnormal neural plate morphology ( J:79457 )

• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

nervous system

abnormal neural plate morphology ( J:79457 )

• E8.25 mutants exhibit midline defects of the neural plate in the prospective forebrain

cardiovascular system

distended pericardium ( J:79457 )

• at E9.5, the pericadial sac is enlarged

craniofacial

abnormal first pharyngeal arch morphology ( J:79457 )

• mandibular component of the first branchial arch is severely reduced

fused first pharyngeal arch ( J:79457 )

• mandibular component of the first branchial arch is fused in the midline

growth/size/body

decreased embryo size ( J:79457 )

• small at E9.5

vision/eye

abnormal optic vesicle formation ( J:79457 )

• incomplete separation of the bilateral evaginations that form the optic vesicles and by E8.5, the bilateral cup-like evaginations are replaced by a deep single evagination