Analysis Tools
nervous system
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• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
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• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age
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behavior/neurological
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• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
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• in a novel arena at 2 and 12 months but not at 4 months
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homeostasis/metabolism
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• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:154968 | ||
| cerebral amyloid angiopathy | DOID:9246 | J:154968 | ||
