Phenotypes associated with this allele

• Allele Symbol: Adam15^tm1Bbl
• Allele Name: targeted mutation 1, Carl P Blobel
• Allele ID: MGI:2672997
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam15^tm1Bbl/Adam15^tm1Bbl	129X1/SvJ-Adam15^tm1Bbl	MGI:2673005
hm2	Adam15^tm1Bbl/Adam15^tm1Bbl	B6.129X1-Adam15^tm1Bbl	MGI:2673036
hm3	Adam15^tm1Bbl/Adam15^tm1Bbl	involves: 129X1/SvJ * C57BL/6J	MGI:2673035
cx4	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^Gt(Betageo)1Bbl/Adam19^Gt(Betageo)1Bbl Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3654840
cx5	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam17^tm1Imx/Adam17^tm1Imx Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3056935
cx6	Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^Gt(Betageo)1Bbl/Adam19^Gt(Betageo)1Bbl	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3654839

Genotype
MGI:2673005

hm1

• Allelic Composition: Adam15^tm1Bbl/Adam15^tm1Bbl
• Genetic Background: 129X1/SvJ-Adam15^tm1Bbl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal induced retina neovascularization ( J:84800 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy

vision/eye

abnormal induced retina neovascularization ( J:84800 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy

Genotype
MGI:2673036

hm2

• Allelic Composition: Adam15^tm1Bbl/Adam15^tm1Bbl
• Genetic Background: B6.129X1-Adam15^tm1Bbl

neoplasm

decreased tumor growth/size ( J:84800 )

• the size of tumors resulting from implanted melanoma cells is significantly smaller than in wild-type controls

• however, the histological morphology and vascular density of the tumors is similar to wild-type controls

cardiovascular system

abnormal induced retina neovascularization ( J:84800 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy

vision/eye

abnormal induced retina neovascularization ( J:84800 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy

Genotype
MGI:2673035

hm3

• Allelic Composition: Adam15^tm1Bbl/Adam15^tm1Bbl
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

neoplasm

decreased tumor growth/size ( J:217858 )

• size of tumors produced by heterotopically injected melanoma cells is reduced as compared to wild-type

abnormal tumor susceptibility ( J:84800 , J:217858 )

• the size of tumors resulting from implanted melanoma cells is significantly smaller than in wild-type controls (J:84800)

• the histological morphology and vascular density of the tumors is similar to wild-type controls (J:84800)

• 54% of mutant mice produce tumors as compared to 75.6% of wild-type mice (J:217858)

decreased tumor incidence ( J:217858 )

• number of tumors produced by heterotopically injected melanoma cells is reduced as compared to wild-type

cardiovascular system

abnormal induced retina neovascularization ( J:84800 , J:217858 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy (J:84800)

• the tortuosity index of major retinal vessels is increased in response to oxygen-induced retinopathy (J:217858)

vision/eye

abnormal induced retina neovascularization ( J:84800 , J:217858 )

• while developmental angiogenesis is normal, pathological neovascularization of the retina is reduced relative to wild-type controls in response to hypoxia-induced proliferative retinopathy (J:84800)

• the tortuosity index of major retinal vessels is increased in response to oxygen-induced retinopathy (J:217858)

Genotype
MGI:3654840

cx4

• Allelic Composition: Adam12^tm1Asf/Adam12^tm1Asf; Adam15^tm1Bbl/Adam15^tm1Bbl; Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}; Adam9^tm1Bbl/Adam9^tm1Bbl
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

perinatal lethality, incomplete penetrance ( J:99649 )

• significantly less (4.6%) than the expected Mendelian ratio of 25% of mutants is seen at birth, however normal numbers are seen at E18.5 although less than 1/3 have a visible heartbeat at this time

cardiovascular system

double outlet right ventricle ( J:99649 )

• both the aorta and pulmonic artery emanate from the right ventricle, a more severe malrotation defect than seen in single homozygous Adam19 mutant mice

ventricular septal defect ( J:99649 )

• exhibit a ventricular septal defect at E18.5

abnormal heart valve morphology ( J:99649 )

abnormal mitral valve morphology ( J:99649 )

• thicker and misshapen mitral valve

thick mitral valve ( J:99649 )

abnormal tricuspid valve morphology ( J:99649 )

• misshapen tricuspid valve

tricuspid valve hyperplasia ( J:99649 )

• hyperplastic tricuspid valve

semilunar valve hyperplasia ( J:99649 )

• hyperplastic semilunar valves

Genotype
MGI:3056935

cx5

• Allelic Composition: Adam12^tm1Asf/Adam12^tm1Asf; Adam15^tm1Bbl/Adam15^tm1Bbl; Adam17^tm1Imx/Adam17^tm1Imx; Adam9^tm1Bbl/Adam9^tm1Bbl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality ( J:88801 )

cardiovascular system

abnormal mitral valve morphology ( J:88801 )

• thickened and misshapen valves

thick mitral valve ( J:88801 )

abnormal tricuspid valve morphology ( J:88801 )

• thickened and misshapen valves

thick tricuspid valve ( J:88801 )

abnormal aortic valve morphology ( J:88801 )

• thickened and misshapen valves

thick aortic valve ( J:88801 )

abnormal pulmonary valve morphology ( J:88801 )

• thickened and misshapen valves

thick pulmonary valve ( J:88801 )

vision/eye

eyelids open at birth ( J:88801 )

Genotype
MGI:3654839

cx6

• Allelic Composition: Adam15^tm1Bbl/Adam15^tm1Bbl; Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl}
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

cardiovascular system

abnormal tricuspid valve morphology ( J:99649 )

• thicker and misshapen tricuspid valve, similar to that seen in single homozygous Adam 19 mutants, however have normal mitral vavles and do not exhibit double outlet right ventricle

thick tricuspid valve ( J:99649 )