Phenotypes associated with this allele

• Allele Symbol: Trim25^tm1Mura
• Allele Name: targeted mutation 1, Masami Muramatsu
• Allele ID: MGI:2673138
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim25^tm1Mura/Trim25^tm1Mura	involves: 129S4/SvJae	MGI:6149724
hm2	Trim25^tm1Mura/Trim25^tm1Mura	involves: 129/Sv * 129S4/SvJae	MGI:2673142
cx3	Trim25^tm1Mura/Trim25^+ Usp15^L749R/Usp15^+	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J	MGI:6149725

Genotype
MGI:6149724

hm1

• Allelic Composition: Trim25^tm1Mura/Trim25^tm1Mura
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

immune system

decreased susceptibility to parasitic infection ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

Genotype
MGI:2673142

hm2

• Allelic Composition: Trim25^tm1Mura/Trim25^tm1Mura
• Genetic Background: involves: 129/Sv * 129S4/SvJae

reproductive system

small uterus ( J:77296 )

♀ • underdeveloped when studied in the secretory phase of the cycle

♀ • unresponsive to estrogen-induced uterine growth after ovariectomy

Genotype
MGI:6149725

cx3

• Allelic Composition: Trim25^tm1Mura/Trim25⁺; Usp15^L749R/Usp15⁺
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)