Analysis Tools
behavior/neurological
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• homozygous mice spend less time exploring open arms in the elevated plus-maze test
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• mice demonstrate increased tendency to stay at the sides of an open field box and spent less time in active locomotion or rearing activity
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• increased mean latency in jumping response in the hot-plate test, but no difference in the tail-flick test
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• males do not initiate copulatory behavior
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endocrine/exocrine glands
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• appear vacuolated
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• degeneration noted with age
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small testis
(
J:69615
)
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growth/size/body
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• the body weight of homozygous animals at 7 weeks of age are approximately 70% of controls
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homeostasis/metabolism
reproductive system
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• little or no movement; do not fertilize oocytes in vitro
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• appear vacuolated
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• degeneration noted with age
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small testis
(
J:69615
)
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• absent spermatozoa
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• decreased number of late spermatids
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• males do not plug females
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cellular
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• decreased number of late spermatids
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• little or no movement; do not fertilize oocytes in vitro
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