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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		In(11Trp53;11Wnt3)8Brd
inversion, Chr 11, Allan Bradley 8
MGI:2673211
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		In(11Trp53;11Wnt3)8Brd/In(11Trp53;11Wnt3)8Brd involves: 129S7/SvEvBrd * C57BL/6Brd MGI:2673217
cx2
 		A/a
In(11Trp53;11Wnt3)8Brd/+ 		either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J) MGI:5766498
cx3
 		In(11Trp53;11Wnt3)8Brd/+
Tyrc-Brd/Tyrc-Brd 		involves: 129S7/SvEvBrd * C57BL/6Brd MGI:5766501
cx4
 		a/a
In(11Trp53;11Wnt3)8Brd/+ 		involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J MGI:5766500
cx5
 		In(11Trp53;11Wnt3)8Brd/+
Rpl27aSfa/Rpl27a+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5140360


Genotype
MGI:2673217
hm1
Allelic
Composition		 In(11Trp53;11Wnt3)8Brd/In(11Trp53;11Wnt3)8Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:56548 )
• homozygous embryos are inviable




Genotype
MGI:5766498
cx2
Allelic
Composition		 A/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background		 either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

growth/size/body
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

hearing/vestibular/ear
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

integument
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:5766501
cx3
Allelic
Composition		 In(11Trp53;11Wnt3)8Brd/+
Tyrc-Brd/Tyrc-Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
Tyrc-Brd mutation (8 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:56548 )
N
• the inversion has no effect on coat color in an albino background, suggesting the tyrosinase minigene in the Trp53 gene is inactive in the inversion chromosome.




Genotype
MGI:5766500
cx4
Allelic
Composition		 a/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:5140360
cx5
Allelic
Composition		 In(11Trp53;11Wnt3)8Brd/+
Rpl27aSfa/Rpl27a+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
Rpl27aSfa mutation (0 available); any Rpl27a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:174216 )
• mice do not display ataxia or foot pad hyperpigmentation




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory