Phenotypes associated with this allele

• Allele Symbol: Gata2^tm1Mym
• Allele Name: targeted mutation 1, Masayuki Yamamoto
• Allele ID: MGI:2673268
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata2^tm1Mym/Gata2^tm1Mym	involves: 129P2/OlaHsd * C57BL/6	MGI:3047301
ht2	Gata2^tm1Mym/Gata2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3620765

Genotype
MGI:3047301

hm1

• Allelic Composition: Gata2^tm1Mym/Gata2^tm1Mym
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84836 , J:106045 )

• die between E9.5 and E11.5 (J:84836)

hematopoietic system

abnormal blood cell morphology/development ( J:84836 )

• at E9.5, but not in older embryos, increased numbers of CD45+ cells and decreased numbers of CD45^low cells are seen in the yolk sac suggesting depletion of the precursor cells

abnormal definitive hematopoiesis ( J:106045 )

• at E10, severely reduced numbers of hematopoietic cells are present

Genotype
MGI:3620765

ht2

• Allelic Composition: Gata2^tm1Mym/Gata2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

abnormal definitive hematopoiesis ( J:84836 )

• at E9.5, slightly increased numbers of CD45+ cells are seen in the yolk sac and at E11.5 impaired production of CD45+ and CD34+ cells is seen in the aorta-gonads-mesonephros region suggesting depletion of the precursor cells