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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat3tm1Desi
targeted mutation 1, Stephen Desiderio
MGI:2673309
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat3tm1Desi/Stat3tm1Desi involves: 129X1/SvJ * C57BL/6 MGI:2673311


Genotype
MGI:2673311
hm1
Allelic
Composition		 Stat3tm1Desi/Stat3tm1Desi
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Desi mutation (1 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to endotoxin shock ( J:77307 )
• mutants challenged with bacterial lipopolysaccharide exhibit diminished recovery from endotoxic shock and exhibit severe acute tubular necrosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory