Phenotypes associated with this allele

• Allele Symbol: Entpd1^tm1Djp
• Allele Name: targeted mutation 1, David J Pinsky
• Allele ID: MGI:2673318
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Entpd1^tm1Djp/Entpd1^tm1Djp	B6.129-Entpd1^tm1Djp	MGI:3826688
hm2	Entpd1^tm1Djp/Entpd1^tm1Djp	involves: 129 * C57BL/6	MGI:2673320

Genotype
MGI:3826688

hm1

• Allelic Composition: Entpd1^tm1Djp/Entpd1^tm1Djp
• Genetic Background: B6.129-Entpd1^tm1Djp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

impaired smooth muscle contractility ( J:143010 )

• electrical field stimulation of vas deferens smooth muscle results in a depression of both the initial rapid muscle contraction and the later sustained contraction

• muscle contractility unaffected by administration of pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid

• muscle contractility unaffected by administration of ectonucleoside triphosphate diphosphohydrolase 1

• muscle contractility unaffected by administration of nucleotidase inhibitor

• no purinergic receptor desensitization by alpha beta methylene ATP and attenuated postsynaptic response to alpha beta methylene ATP

abnormal muscle electrophysiology ( J:143010 )

• electrical field stimulation of vas deferens smooth muscle results in a depression of both the initial rapid muscle contraction and the later sustained contraction

nervous system

abnormal neurotransmitter secretion ( J:143010 )

• ATP release after a depolarizing is relatively less than for controls using cardiac synaptosomal preparations to study synaptic nerve endings

abnormal synaptic norepinephrine release ( J:143010 )

• alpha beta methylene ATP induced release of norepinephrine is about 10 fold less effective than in controls

increased neurotransmitter release ( J:143010 )

• basal ATP release is 2-3X higher than in controls

homeostasis/metabolism

decreased platelet aggregation ( J:143010 )

• reduced platelet aggregation response to ADP

hematopoietic system

decreased platelet aggregation ( J:143010 )

• reduced platelet aggregation response to ADP

Genotype
MGI:2673320

hm2

• Allelic Composition: Entpd1^tm1Djp/Entpd1^tm1Djp
• Genetic Background: involves: 129 * C57BL/6

nervous system

increased susceptibility to ischemic brain injury ( J:76092 )

• after being subjected to focal cerebral ischemia, diminished blood flow following reperfusion is observed relative to wild-type controls

increased cerebral infarct size ( J:76092 )

• increased cerebral infarction volume following induced stroke

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:76092 )

N • bleeding times are normal

abnormal platelet physiology ( J:76092 )

• slightly reduced platelet reactivity to 10 microM ADP

increased susceptibility to ischemic brain injury ( J:76092 )

• after being subjected to focal cerebral ischemia, diminished blood flow following reperfusion is observed relative to wild-type controls

increased cerebral infarct size ( J:76092 )

• increased cerebral infarction volume following induced stroke

hematopoietic system

hematopoietic system phenotype ( J:76092 )

N • hematological profiles are normal

abnormal platelet physiology ( J:76092 )

• slightly reduced platelet reactivity to 10 microM ADP