All Phenotypes Adamts20<bt-Bei1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adamts20^bt-Bei1
belted 1 David Beier
MGI:2673334

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts20^bt-Bei1/Adamts20^bt-Bei1	B6.Cg-Adamts20^bt-Bei1	MGI:4418760
hm2	Adamts20^bt-Bei1/Adamts20^bt-Bei1	involves: C57BL/6	MGI:2673338
cx3	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418755
cx4	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts5^tm1Dgen/Adamts5^tm1Dgen	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418858
cx5	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418759
cx6	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts5^tm1Dgen/Adamts5⁺	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418757
cx7	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1	MGI:4418877
cx8	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418861
cx9	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418865
cx10	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603312
cx11	Adamts20^bt-Bei1/Adamts20⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari	involves: 129S4/SvJaeSor * C57BL/6J * DBA/2 * SJL	MGI:6414583
cx12	Adamts20^bt-Bei1/Adamts20^bt-Bei1 B3glct^tm1.2Nari/B3glct^tm1.2Nari	involves: 129S4/SvJaeSor * C57BL/6J * DBA/2 * SJL	MGI:6414585

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1
Genetic Background	B6.Cg-Adamts20^bt-Bei1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 18% penetrance of syndactyly

• forelimbs are more frequently affected

interdigital webbing ( J:155754 )

nervous system

hydrocephaly ( J:286130 )

• 4 of 9 mice develop hydrocephalus between 3 and 6 weeks of age

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:84755 )

• belted appearance of coat

integument

belted ( J:84755 )

• belted appearance of coat

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen
Genetic Background	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5^tm1Dgen mutation (1 available); any Adamts5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts5^tm1Dgen/Adamts5^tm1Dgen
Genetic Background	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal interdigital cell death ( J:155754 )

• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections

• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs

• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant

syndactyly ( J:155754 )

• soft-tissue syndactyly (STS) with 100% penetrance

• at least three of four limbs are involved

• the interdigital tissue (IDT) between hindlimb digits 3 and 4 is most frequently involved and has the greatest severity of STS

• persistence of the IDT with a low cell density and loose, amorphous matrix

• reduced versican clearance

interdigital webbing ( J:155754 )

• syndactyly is caused by the persistence of the skin web between the digits

• no osseous syndactyly or patterning defects

cellular

abnormal interdigital cell death ( J:155754 )

• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections

• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs

• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺
Genetic Background	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts5^tm1Dgen/Adamts5⁺
Genetic Background	B6.Cg-Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS, n=5)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• fully penetrant soft-tissue syndactyly (STS)

• more affected limbs than littermate control

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

digestive/alimentary system

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

embryo

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

growth/size/body

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

integument

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

limbs/digits/tail

syndactyly ( J:213412 )

• soft tissue syndactly

nervous system

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

pigmentation

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
B3glct^tm1.2Nari mutation (0 available); any B3glct mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality ( J:286130 )

• fewer than the expected numbers of mice are seen

craniofacial

cleft palate ( J:286130 )

• 1 of 4 mutants exhibit cleft palate at E18.5

growth/size/body

cleft palate ( J:286130 )

• 1 of 4 mutants exhibit cleft palate at E18.5

digestive/alimentary system

cleft palate ( J:286130 )

• 1 of 4 mutants exhibit cleft palate at E18.5

integument

white spotting ( J:286130 )

• mice exhibit a high penetrance of white spotting in the lumbar region; white spotting does not increase in severity to what is seen in single homozygous B3glct^tm1.2Nari mutants

pigmentation

white spotting ( J:286130 )

• mice exhibit a high penetrance of white spotting in the lumbar region; white spotting does not increase in severity to what is seen in single homozygous B3glct^tm1.2Nari mutants

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 B3glct^tm1.2Nari/B3glct^tm1.2Nari
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * DBA/2 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality ( J:286130 )

• no mice are obtained at weaning

craniofacial

cleft palate ( J:286130 )

• 9 of 11 mutants exhibit cleft palate at E18.5

digestive/alimentary system

cleft palate ( J:286130 )

• 9 of 11 mutants exhibit cleft palate at E18.5

growth/size/body

cleft palate ( J:286130 )

• 9 of 11 mutants exhibit cleft palate at E18.5

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