Phenotypes associated with this allele

• Allele Symbol: Cxcl13^tm1Mmi
• Allele Name: targeted mutation 1, Masayuki Miyasaka
• Allele ID: MGI:2673341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl13^tm1Mmi/Cxcl13^tm1Mmi	involves: C57BL/6	MGI:3046913

Genotype
MGI:3046913

hm1

• Allelic Composition: Cxcl13^tm1Mmi/Cxcl13^tm1Mmi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display reduced migration into the mesenteric lymph nodes (LNs) but normal migration into the spleen

• in contrast, coinjected T cells show normal migration into both mesenteric LNs and spleen

abnormal leukocyte adhesion ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display normal rolling but fail to adhere to the luminal surface of HEVs in PPs; in contrast, T cells roll and arrest as efficiently as in wild-type controls

• reconstitution of luminal CXCL13 presentation in PP HEVs restores B cell sticking although to a lesser extent than observed in wild-type controls

abnormal B cell physiology ( J:84804 )

• homozygotes display impaired B cell trafficking across high endothelial venules (HEVs) in Peyer's patches (PPs)

cellular

abnormal leukocyte migration ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display reduced migration into the mesenteric lymph nodes (LNs) but normal migration into the spleen

• in contrast, coinjected T cells show normal migration into both mesenteric LNs and spleen

abnormal leukocyte adhesion ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display normal rolling but fail to adhere to the luminal surface of HEVs in PPs; in contrast, T cells roll and arrest as efficiently as in wild-type controls

• reconstitution of luminal CXCL13 presentation in PP HEVs restores B cell sticking although to a lesser extent than observed in wild-type controls

hematopoietic system

abnormal leukocyte migration ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display reduced migration into the mesenteric lymph nodes (LNs) but normal migration into the spleen

• in contrast, coinjected T cells show normal migration into both mesenteric LNs and spleen

abnormal leukocyte adhesion ( J:84804 )

• when injected into homozygotes, fluorescently labeled B cells display normal rolling but fail to adhere to the luminal surface of HEVs in PPs; in contrast, T cells roll and arrest as efficiently as in wild-type controls

• reconstitution of luminal CXCL13 presentation in PP HEVs restores B cell sticking although to a lesser extent than observed in wild-type controls

abnormal B cell physiology ( J:84804 )

• homozygotes display impaired B cell trafficking across high endothelial venules (HEVs) in Peyer's patches (PPs)