All Phenotypes Egfr<tm2(EGFR)Wag> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfr^tm2(EGFR)Wag/Egfr^tm2(EGFR)Wag	involves: 129	MGI:2673652
hm2	Egfr^tm2(EGFR)Wag/Egfr^tm2(EGFR)Wag	involves: 129/Sv * C57BL/6	MGI:2673649
ht3	Egfr^tm1Wag/Egfr^tm2(EGFR)Wag	involves: 129	MGI:2673651
ht4	Egfr^tm1Wag/Egfr^tm2(EGFR)Wag	involves: 129/Sv * C57BL/6	MGI:2673650

Allelic Composition	Egfr^tm2(EGFR)Wag/Egfr^tm2(EGFR)Wag
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm2(EGFR)Wag mutation (0 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:84870 )

• complete penetrance

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:84870 )

• increased lethality prior to 6 months of age due to cardiac hypertrophy

prenatal lethality, incomplete penetrance ( J:84870 )

• incomplete penetrance, 7% of homozygous mutant mice were born alive

cardiovascular system

cardiac hypertrophy ( J:84870 )

• contributing to increased lethality

• apparent 3 weeks after birth in some mice

heart left ventricle hypertrophy ( J:84870 )

abnormal semilunar valve morphology ( J:84870 )

growth/size/body

cardiac hypertrophy ( J:84870 )

• contributing to increased lethality

• apparent 3 weeks after birth in some mice

heart left ventricle hypertrophy ( J:84870 )

decreased body size ( J:84870 )

decreased body weight ( J:84870 )

postnatal growth retardation ( J:84870 )

skeleton

enhanced osteoblast differentiation ( J:84870 )

• accelerated osteoblast differentiation

premature chondrocyte differentiation ( J:84870 )

• accelerated chondrocyte differentiation

nervous system

nervous system phenotype ( J:84870 )

N	• in contrast to null mice, normal architecture and morphology was observed in various sections of the brain including the frontal cortex, hippocampus, olfactory bulb, thalamus, and cerebellum

integument

alopecia ( J:84870 )

• by 5 to 7 months of age due to progressive degeneration of hair follicles

delayed hair appearance ( J:84870 )

short hair ( J:84870 )

sparse hair ( J:84870 )

abnormal hair follicle orientation ( J:84870 )

decreased hair follicle number ( J:84870 )

• progressive degeneration and inflammation led to the loss of most follicles over time, leading to baldness by 5 to 7 months of age

curly vibrissae ( J:84870 )

abnormal hair cycle ( J:84870 )

cellular

enhanced osteoblast differentiation ( J:84870 )

• accelerated osteoblast differentiation

muscle

heart left ventricle hypertrophy ( J:84870 )

Allelic Composition	Egfr^tm1Wag/Egfr^tm2(EGFR)Wag
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Wag mutation (0 available); any Egfr mutation (87 available)
Egfr^tm2(EGFR)Wag mutation (0 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:84870 )

• complete penetrance

Allelic Composition	Egfr^tm1Wag/Egfr^tm2(EGFR)Wag
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:84870 )

• complete penetrance

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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