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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map2k6tm1Flv
targeted mutation 1, Richard A Flavell
MGI:2673716
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map2k6tm1Flv/Map2k6tm1Flv involves: 129S1/Sv MGI:2673719


Genotype
MGI:2673719
hm1
Allelic
Composition
Map2k6tm1Flv/Map2k6tm1Flv
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6tm1Flv mutation (1 available); any Map2k6 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• impaired cell death of double positive thymocytes after injection of anti-CD3 mAb, however the thymus and spleen were histologically normal and the lymphoid compartments contained normal numbers of thymocytes and splenocytes displaying normal surface marker expression

cellular
• at doses of 300 and 1000 rad of gamma radiation, a small but significant decrease in the susceptibility to cell death is seen in CD4+ T cells
• impaired cell death of double positive thymocytes after injection of anti-CD3 mAb, however the thymus and spleen were histologically normal and the lymphoid compartments contained normal numbers of thymocytes and splenocytes displaying normal surface marker expression

hematopoietic system
• impaired cell death of double positive thymocytes after injection of anti-CD3 mAb, however the thymus and spleen were histologically normal and the lymphoid compartments contained normal numbers of thymocytes and splenocytes displaying normal surface marker expression

endocrine/exocrine glands
• impaired cell death of double positive thymocytes after injection of anti-CD3 mAb, however the thymus and spleen were histologically normal and the lymphoid compartments contained normal numbers of thymocytes and splenocytes displaying normal surface marker expression





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory