All Phenotypes Mdm2<tm1.1Mep> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm2^tm1.1Mep
targeted mutation 1.1, Mary Ellen Perry
MGI:2673928

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm1.1Mep/Mdm2^tm1.1Mep	involves: 129S7/SvEvBrd * C57BL/6	MGI:3715444
ht2	Mdm2^tm1Mep/Mdm2^tm1.1Mep	involves: 129S7/SvEvBrd * C57BL/6 * FVB	MGI:3715446
ht3	Mdm2^tm1Bay/Mdm2^tm1.1Mep	involves: 129S7/SvEvBrd * C57BL/6 * FVB	MGI:3715441

Allelic Composition	Mdm2^tm1.1Mep/Mdm2^tm1.1Mep
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:81065 )

• no homozygous offspring are produced

Allelic Composition	Mdm2^tm1Mep/Mdm2^tm1.1Mep
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)
Mdm2^tm1Mep mutation (1 available); any Mdm2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:81065 )

• at 5 weeks of age, a 15-20% reduction in body weight is observed relative to wild-type mice

hematopoietic system

decreased thymus weight ( J:81065 )

• thymus wet weight is significantly less than in wild-type

decreased spleen weight ( J:81065 )

• spleen wet weight is less than in wild-type

immune system

decreased thymus weight ( J:81065 )

• thymus wet weight is significantly less than in wild-type

decreased spleen weight ( J:81065 )

• spleen wet weight is less than in wild-type

liver/biliary system

decreased liver weight ( J:81065 )

• liver wet weight is significantly less than in wild-type

renal/urinary system

decreased kidney weight ( J:81065 )

• kidney wet weight is less than in wild-type

endocrine/exocrine glands

decreased thymus weight ( J:81065 )

• thymus wet weight is significantly less than in wild-type

Allelic Composition	Mdm2^tm1Bay/Mdm2^tm1.1Mep
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)
Mdm2^tm1Bay mutation (1 available); any Mdm2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:81065 )

• no offspring heterozygous for the two mutant Mdm2 alleles are produced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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