Phenotypes associated with this allele

• Allele Symbol: Gdf3^tm1Zuk
• Allele Name: targeted mutation 1, Martin M Matzuk
• Allele ID: MGI:2673981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf3^tm1Zuk/Gdf3^tm1Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3826274

Genotype
MGI:3826274

hm1

• Allelic Composition: Gdf3^tm1Zuk/Gdf3^tm1Zuk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:143083 )

• fewer than expected mice are born but mice exhibit normal mortality thereafter

prenatal lethality, incomplete penetrance ( J:143083 )

• fewer than expected mice are born

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:143083 )

• when fed a high fat diet, mice fail to exhibit increased weight or white adipose deposit unlike wild-type mice

improved glucose tolerance ( J:143083 )

• compared to wild-type mice when fed a high fat diet

increased basal metabolism ( J:143083 )

• when fed a high fat diet, mice exhibit an increase in basal metabolic rate compared to in similarly treated mice that is not due to hyperactivity and does not lead to changes in body temperature or cold tolerance

growth/size/body

growth/size/body region phenotype ( J:143083 )

N • mice exhibit normal growth and weights when fed a regular diet

decreased susceptibility to diet-induced obesity ( J:143083 )

• when fed a high fat diet, mice fail to exhibit increased weight or white adipose deposit unlike wild-type mice

adipose tissue

decreased white adipose tissue amount ( J:143083 )

• when fed a high fat diet, mice fail to exhibit an increase adipose tissue as in similarly treated wild-type mice

abnormal fat cell morphology ( J:143083 )

• when fed a high fat diet, mice fail to exhibit adipocyte hypertrophy as in similarly treated wild-type mice and adipocytes remain the same size as in mice fed a regular diet