Phenotypes associated with this allele

• Allele Symbol: Serpinb6a^tm1.1Pib
• Allele Name: targeted mutation 1.1, Phillip I Bird
• Allele ID: MGI:2673997
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpinb6a^tm1.1Pib/Serpinb6a^tm1.1Pib	involves: C57BL/6	MGI:3720028

Genotype
MGI:3720028

hm1

• Allelic Composition: Serpinb6a^tm1.1Pib/Serpinb6a^tm1.1Pib
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89890 )

• homozygous mice develop normally and are fertile, with no abnormal pathology or increased sensitivity to cerebral ischemia

• no perturbations in leukocyte development or numbers

• recruitment of leukocytes to the peritoneal cavity is normal

• mutant mice are equally susceptible as control mice to systemic Candida albicans infection

• increased levels of a related inhibitor Serpinb1 (monocyte/neutrophil elastase inhibitor) in the tissues of targeted mice suggests that compensation by other serpins reduces the impact of Serpinb6 deficiency in these animals