Phenotypes associated with this allele

• Allele Symbol: Hint1^tm1Ibw
• Allele Name: targeted mutation 1, I Bernard Weinstein
• Allele ID: MGI:2674018
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hint1^tm1Ibw/Hint1^tm1Ibw	involves: 129 * C57BL/6	MGI:2674073

Genotype
MGI:2674073

hm1

• Allelic Composition: Hint1^tm1Ibw/Hint1^tm1Ibw
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:84504 )

• increase in susceptibillity to NMBA-induced tumors, with a greater incidence, multiplicity per mouse, volume, and degree of malignancy relative to wild-type mice

• mutants develop adenomas and adenocarcinoma of the glandular stomach, tumors not seen in NMBA-treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:84504 )

• increase in susceptibillity to NMBA-induced tumors, with a greater incidence, multiplicity per mouse, volume, and degree of malignancy relative to wild-type mice

• mutants develop adenomas and adenocarcinoma of the glandular stomach, tumors not seen in NMBA-treated wild-type mice

cellular

decreased cellular sensitivity to gamma-irradiation ( J:84504 )

• MEFs show increased resistance to cytotoxicity by ionizing radiation

increased fibroblast proliferation ( J:84504 )

• mouse embryonic fibroblasts (MEFs) when serially passaged, exhibit an increase in growth rate and undergo spontaneous immortalization instead of senescing

growth/size/body

decreased body weight ( J:84504 )

♂ • males, but not females, exhibit decreased body weight from 3 to 11 months of age