Analysis Tools|
Allele Symbol Allele Name Allele ID |
Brd4Gt(pGT1.8TM)ST132Nimr gene trap ST132, National Institute for Medical Research MGI:2674141 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos die between E3.0 and E8.0
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• by E8.0, the inner cell mass had degenerated completely
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of heterozygous animals die within the first two weeks of birth
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• short incisive bone
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• short and bent nasal bone
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• lacking spermatogenic cells
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• short and bent nasal bone
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• at E10 through birth, heterozygous embryos weighed 25% less than littermates;
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• after birth, heterozygous embryos weighed 10% less than littermates
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• abnormal nuclear morphology; enlarged, or cells contained two nuclei; degenerated and/or necrotic hepatocytes detected
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• lacking spermatogenic cells
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• impaired spermatogenesis
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• cells lining ducts of abnormal size/shape and abnormal nuclear morphology
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• cells lining ducts of abnormal size/shape and abnormal nuclear morphology
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• short incisive bone
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• short and bent nasal bone
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• seen in 4 of 34 animals
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• at E10 through birth, heterozygous embryos weighed 25% less than littermates;
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• increased number of neutrophils and mature fibrocytes in dermis
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• short and bent nasal bone
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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