Phenotypes associated with this allele

• Allele Symbol: Meox2^tm1Vpa
• Allele Name: targeted mutation 1, Vassilis Pachnis
• Allele ID: MGI:2674242
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meox2^tm1Vpa/Meox2^tm1Vpa	involves: 129P2/OlaHsd	MGI:3773056
hm2	Meox2^tm1Vpa/Meox2^tm1Vpa	involves: 129P2/OlaHsd * C57BL/6	MGI:2674256
cx3	Meox1^Tg(Mx1-TAX)2627Arnh/Meox1^Tg(Mx1-TAX)2627Arnh Meox2^tm1Vpa/Meox2^tm1Vpa	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6	MGI:2674287
cx4	Meox1^tm1Bmk/Meox1^tm1Bmk Meox2^tm1Vpa/Meox2^tm1Vpa	involves: 129P2/OlaHsd * C57BL/6	MGI:2674285
cx5	Meox1^tm1Bmk/Meox1^+ Meox2^tm1Vpa/Meox2^tm1Vpa	involves: 129P2/OlaHsd * C57BL/6	MGI:4365295
cx6	Meox1^tm1Bmk/Meox1^tm1Bmk Meox2^tm1Vpa/Meox2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4365367

Genotype
MGI:3773056

hm1

• Allelic Composition: Meox2^tm1Vpa/Meox2^tm1Vpa
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:98439 )

N • perineal muscles form normally

abnormal skeletal muscle morphology ( J:98439 )

• changes in limb muscle pattern are detected

Genotype
MGI:2674256

hm2

• Allelic Composition: Meox2^tm1Vpa/Meox2^tm1Vpa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

decreased survivor rate ( J:56172 )

• some of the least affected (about 20%) mutants survive to adulthood, although 80% die before weaning

postnatal lethality, incomplete penetrance ( J:56172 )

• 80% of mutants are severely afflicted by the limb musculature defect and die prior to weaning

limbs/digits/tail

abnormal limb morphology ( J:56172 )

• abnormal limb muscle development, not due to impaired migration of myogenic precursors into the limb bud

muscle

abnormal muscle development ( J:56172 )

• developmental defect of limb musculature characterized by an overall reduction in muscle mass and elimination of specific muscles

abnormal myogenesis ( J:56172 )

increased variability of skeletal muscle fiber size ( J:56172 )

• variable diameter of skeletal muscle fibers in the fore- and hindlimbs

centrally nucleated skeletal muscle fibers ( J:56172 )

• centrally placed nuclei in skeletal muscle fibers of both fore- and hindlimbs

decreased skeletal muscle mass ( J:56172 )

• neonates show an overall reduction in skeletal muscle mass of the limbs

behavior/neurological

limb grasping ( J:56172 )

• mutants exhibit a limb grasping reflex not observed in controls

abnormal limb posture ( J:56172 )

• abnormal extended position of the forelimbs and hindlimbs

abnormal gait ( J:56172 )

• mutants surviving to adulthood exhibit abnormal gait

craniofacial

cleft secondary palate ( J:56172 )

• 10% of mutants exhibit clefting of the secondary palate

digestive/alimentary system

cleft secondary palate ( J:56172 )

• 10% of mutants exhibit clefting of the secondary palate

growth/size/body

cleft secondary palate ( J:56172 )

• 10% of mutants exhibit clefting of the secondary palate

Genotype
MGI:2674287

cx3

• Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh}; Meox2^tm1Vpa/Meox2^tm1Vpa
• Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:84754 )

• mice are born in Mendelian ratios but died shortly after birth

embryo

abnormal somite development ( J:84754 )

• disrupted somite development, patterning, and differentiation

• absence of ventral (ribs and vertebrae) and dorsal (skeletal muscle) somite derivatives

growth/size/body

decreased body length ( J:84754 )

• newborn pups present with drastically reduced trunk length

limbs/digits/tail

vestigial tail ( J:84754 )

• rudimentary stump lacking skeletal elements

muscle

abnormal skeletal muscle morphology ( J:84754 )

• most skeletal muscles are absent or reduced in size

skeleton

absent ribs ( J:84754 )

absent vertebrae ( J:84754 )

Genotype
MGI:2674285

cx4

• Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk; Meox2^tm1Vpa/Meox2^tm1Vpa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:84754 )

• mice are born in Mendelian ratios but die shortly after birth

embryo

abnormal somite development ( J:84754 )

• disrupted somite development, patterning, and differentiation

• absence of ventral (ribs and vertebrae) and dorsal (skeletal muscle) somite derivatives

abnormal dorsal-ventral polarity of the somites ( J:84754 )

• patterning and specification of the posterior and anterior halves of somites are defective

abnormal somite shape ( J:84754 )

• newly formed somites are irregular in shape and fail to epithelialize

abnormal somite size ( J:84754 )

• newly formed somites are irregularly sized

growth/size/body

decreased body length ( J:84754 )

• newborn pups present with drastically reduced trunk length

limbs/digits/tail

absent caudal vertebrae ( J:84754 )

• tail vertebrae are completely absent

vestigial tail ( J:84754 )

• rudimentary stump lacking skeletal elements

muscle

abnormal myotome development ( J:84754 )

• myotomes of anterior somites are fused ventrally but separated dorsally, a defect in epithelialization

abnormal dermomyotome development ( J:84754 )

• epithelial dermomyotome is absent at E10.5

abnormal skeletal muscle morphology ( J:84754 )

• most skeletal muscles are absent or reduced in size in the mutant, including prevertebral muscles of the neck, the epaxial muscles of the trunk, the hypaxial muscles of the trunk including those of the abdominal wall and intercostal muscles

abnormal epaxial muscle morphology ( J:84754 )

• the epaxial muscles of the trunk are severely depleted

abnormal hypaxial muscle morphology ( J:84754 )

• the hypaxial muscles of the trunk including those of the abdominal wall and intercostal muscles are severely depleted

skeleton

abnormal axial skeleton morphology ( J:84754 )

• mutants lack an axial skeleton

occipital bone hypoplasia ( J:84754 )

• occipital skull bones are hypoplastic

abnormal sternum morphology ( J:84754 )

• sternum develops abnormally

absent ribs ( J:84754 )

• although centers of ossification are seen at the cervical and thoracic levels, normal ribs are not observed

abnormal vertebral column morphology ( J:84754 )

• vertebral column is absent and largely replaced by two strips of fused cartilage, in a position corresponding to the neural arches

abnormal vertebrae morphology ( J:84754 )

• ossified, deformed vertebrae are formed at the cervical and thoracic level but more posterior lumbar vertebrae are present only as cartilage condensations at the position expected of the neural arches

absent caudal vertebrae ( J:84754 )

• tail vertebrae are completely absent

abnormal sclerotome morphology ( J:84754 )

• segmented organization of the ventral sclerotome is lost and instead a uniform unsegmented mesenchyme is observed

• marker analysis indicates perturbed sclerotome differentiation but not specification

adipose tissue

decreased brown adipose tissue amount ( J:84754 )

• brown fat overlying the shoulders muscles is absent

craniofacial

occipital bone hypoplasia ( J:84754 )

• occipital skull bones are hypoplastic

homeostasis/metabolism

cyanosis ( J:84754 )

nervous system

abnormal dorsal root ganglion morphology ( J:84754 )

• dorsal root ganglia are irregular in shape and size and fused together

fused dorsal root ganglion ( J:84754 )

abnormal spinal nerve morphology ( J:84754 )

• spinal nerves are irregular in spacing and direction

integument

loose skin ( J:84754 )

Genotype
MGI:4365295

cx5

• Allelic Composition: Meox1^tm1Bmk/Meox1⁺; Meox2^tm1Vpa/Meox2^tm1Vpa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

abnormal axial skeleton morphology ( J:84754 )

• defects affecting the axial skeleton, however ribs and lumbar vertebrae are normal

abnormal vertebrae morphology ( J:84754 )

• vertebral defects apparent only at posterior levels

caudal vertebral fusion ( J:84754 )

• tail vertebrae are malformed and fused

limbs/digits/tail

caudal vertebral fusion ( J:84754 )

• tail vertebrae are malformed and fused

Genotype
MGI:4365367

cx6

• Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk; Meox2^tm1Vpa/Meox2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

caudal vertebral fusion ( J:84754 )

• tail vertebrae are fused

rib fusion ( J:84754 )

abnormal vertebrae development ( J:84754 )

• posterior to the pelvic girdle, poorly differentiated cartilaginous elements are seen in place of vertebrae

abnormal vertebral body morphology ( J:84754 )

• vertebral bodies are split at the lumbar level

limbs/digits/tail

caudal vertebral fusion ( J:84754 )

• tail vertebrae are fused