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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meox1Tg(Mx1-TAX)2627Arnh
transgene insertion 2627, Heinz Arnheiter
MGI:2674268
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh involves: C3H/HeJ * C57BL/6 MGI:2674286
cx2
 		Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh
Meox2tm1Vpa/Meox2tm1Vpa 		involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 MGI:2674287


Genotype
MGI:2674286
hm1
Allelic
Composition		 Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh
Genetic
Background		 involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox1Tg(Mx1-TAX)2627Arnh mutation (0 available); any Meox1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal rib development ( J:84754 )
• relatively mild defects in sclerotome derived rib bones
abnormal vertebrae development ( J:84754 )
• relatively mild defects in sclerotome dervived vertebrae
hemivertebra ( J:84754 )
• presence of hemivertebrae
vertebral fusion ( J:84754 )
• vertebral and craniovertebral fusions, however no apparent defects in skeletal myogenesis




Genotype
MGI:2674287
cx2
Allelic
Composition		 Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh
Meox2tm1Vpa/Meox2tm1Vpa
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox1Tg(Mx1-TAX)2627Arnh mutation (0 available); any Meox1 mutation (17 available)
Meox2tm1Vpa mutation (0 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:84754 )
• mice are born in Mendelian ratios but died shortly after birth

embryo
abnormal somite development ( J:84754 )
• disrupted somite development, patterning, and differentiation
• absence of ventral (ribs and vertebrae) and dorsal (skeletal muscle) somite derivatives

growth/size/body
decreased body length ( J:84754 )
• newborn pups present with drastically reduced trunk length

limbs/digits/tail
vestigial tail ( J:84754 )
• rudimentary stump lacking skeletal elements

muscle
abnormal skeletal muscle morphology ( J:84754 )
• most skeletal muscles are absent or reduced in size

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory