All Phenotypes Tg(Hoxb7-cre)13Amc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hoxb7-cre)13Amc
transgene insertion 13, Andrew P McMahon
MGI:2675121

Summary

21 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(KOMP)Wtsi} Tg(Hoxb7-cre)13Amc/?	B6J.B6-Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(Komp)Wtsi} Tg(Hoxb7-cre)13Amc	MGI:5311855
cn2	Shh^tm1Amc/Shh^tm2Amc Tg(Hoxb7-cre)13Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5441067
cn3	Itgb1^tm1Ross/Itgb1^tm1Ross Tg(Hoxb7-cre)13Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5289691
cn4	Lin7c^tm2Dsb/Lin7c^tm2Dsb Tg(Hoxb7-cre)13Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804963
cn5	Spry1^tm1Jdli/Spry1^tm1Jdli Tg(Hoxb7-cre)13Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3574644
cn6	Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Hoxb7-cre)13Amc/0	involves: 129S4/SvJae * C57BL/6	MGI:6188648
cn7	Crkl^{tm1c(EUCOMM)Hmgu}/Crkl^{tm1c(EUCOMM)Hmgu} Tg(Hoxb7-cre)13Amc/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6N	MGI:7660801
cn8	Ift20^tm1.1Gjp/Ift20^tm1.1Gjp Tg(Hoxb7-cre)13Amc/0	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:3817270
cn9	Gt(ROSA)26Sor^tm1Sor/? Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Tg(Hoxb7-cre)13Amc/0	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:3829882
cn10	Lhx1^tm2.1Bhr/Lhx1^tm1Tmj Tg(Hoxb7-cre)13Amc/0	involves: 129S/SvEv * C57BL/6	MGI:3580500
cn11	Scnn1a^tm1.1Hum/Scnn1a^tm1.1Hum Tg(Hoxb7-cre)13Amc/0	involves: 129/Sv * C57BL/6	MGI:4460805
cn12	Aqp2^tm1Nlsn/Aqp2^tm1Nlsn Tg(Hoxb7-cre)13Amc/0	involves: 129/Sv * C57BL/6	MGI:3626345
cn13	Gt(ROSA)26Sor^{tm1(RARA*)Clmd}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster	MGI:4431229
cn14	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster	MGI:4431231
cn15	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0	involves: 129/SvEv * C57BL/6 * Swiss Webster	MGI:4431228
cn16	Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Tg(Hoxb7-cre)13Amc/0	involves: 129X1/SvJ * C57BL/6	MGI:3829881
cn17	Gfra1^tm2Jmi/Gfra1^tm3Jmi Tg(Hoxb7-cre)13Amc/0	involves: 129X1/SvJ * C57BL/6	MGI:5514419
cn18	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Hoxb7-cre)13Amc/0	involves: 129X1/SvJ * C57BL/6	MGI:5289781
cn19	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3716215
cn20	Cyp2c23^tm1.1Jhc/Cyp2c23^tm1.1Jhc Tg(Hoxb7-cre)13Amc/0	involves: C57BL/6	MGI:5695613
cn21	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Tg(Hoxb7-cre)13Amc/0	involves: C57BL/6	MGI:5548191

Allelic Composition	Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(KOMP)Wtsi} Tg(Hoxb7-cre)13Amc/?
Genetic Background	B6J.B6-Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(Komp)Wtsi} Tg(Hoxb7-cre)13Amc
Cell Lines	EPD0073_5_F01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift140^{tm1b(KOMP)Wtsi} mutation (0 available); any Ift140 mutation (71 available)
Ift140^{tm1c(KOMP)Wtsi} mutation (0 available); any Ift140 mutation (71 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:181533 )

decreased kidney epithelial cell primary cilium length ( J:181533 )

• either very short or no cilia are present in collecting ducts at birth

• cilia continue to be present in decreasing numbers at 10 and 20 days of age

kidney cyst ( J:181533 )

• extensive cysts throughout the kidney by 20 days of age

kidney cortex cyst ( J:181533 )

• present at 10 days of age

kidney medulla cyst ( J:181533 )

• present at 5 and 10 days of age

abnormal kidney collecting duct morphology ( J:181533 )

• only very short cilia are assembled

dilated kidney collecting duct ( J:181533 )

• at birth

• stumpy cilia present at at 10 and 20 days of age

renal fibrosis ( J:181533 )

• cystic kidneys are fibrotic

• increased interstitial cell smooth muscle actin

• increased collagen

abnormal kidney physiology ( J:181533 )

increased kidney apoptosis ( J:181533 )

• at 20 days of age in non-collecting duct cells

increased kidney cell proliferation ( J:181533 )

• percentage of mitotic cells is elevated and remains high in collecting ducts

kidney failure ( J:181533 )

• during the third week of life

cellular

cellular phenotype ( J:181533 )

N	• normal orientation of mitotic spindles in precystic collecting ducts of the kidney

decreased kidney epithelial cell primary cilium length ( J:181533 )

• either very short or no cilia are present in collecting ducts at birth

• cilia continue to be present in decreasing numbers at 10 and 20 days of age

increased kidney apoptosis ( J:181533 )

• at 20 days of age in non-collecting duct cells

increased kidney cell proliferation ( J:181533 )

• percentage of mitotic cells is elevated and remains high in collecting ducts

growth/size/body

kidney cyst ( J:181533 )

• extensive cysts throughout the kidney by 20 days of age

kidney cortex cyst ( J:181533 )

• present at 10 days of age

kidney medulla cyst ( J:181533 )

• present at 5 and 10 days of age

Allelic Composition	Shh^tm1Amc/Shh^tm2Amc Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Amc mutation (1 available); any Shh mutation (48 available)
Shh^tm2Amc mutation (1 available); any Shh mutation (48 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal glomerulus morphology ( J:79481 )

• at the newborn stage, cortical glomerular density is increased by 24% while glomerular density of the whole kidney is increased by 26% relative to that in wild-type controls

• however, no gross differences in glomerular size are observed

decreased renal glomerulus number ( J:79481 )

• newborn mice exhibit a 40% reduction in glomerular number

kidney cortex hypoplasia ( J:79481 )

• at the newborn stage, cortical volume is reduced by 51%

abnormal kidney inner medulla morphology ( J:79481 )

• at 4 months of age, most of the inner medulla is lost in hydronephric kidneys

abnormal kidney outer medulla inner stripe morphology ( J:79481 )

• at 4 months of age, most of the inner stripe of the outer medulla is lost in hydronephric kidneys

kidney medulla hypoplasia ( J:79481 )

• at the newborn stage, medullary volume is reduced by 46%

hydronephrosis ( J:79481 )

• at 4 months of age, 50% of mice exhibit hydronephrosis

• however, no hydronephrosis is detected in newborn pups

small kidney ( J:79481 )

• neonatal kidneys are 52% smaller than wild-type kidneys

renal hypoplasia ( J:79481 )

abnormal ureter development ( J:79481 )

• at E14.5, fewer mesenchymal cells line the ureteral epithelium relative to wild-type controls

• at E14.5, the mitotic index of the proximal and distal ureter mesenchyme is ~50% of that in wild-type controls, indicating reduced cell proliferation

• however, no differences in ureteral mesenchyme apoptosis are observed by TUNEL analysis

abnormal ureter smooth muscle morphology ( J:79481 )

• a delay in smooth muscle differentiation is observed along the proximodistal axis of the ureter

• at E15.0, no smooth muscle alpha-actin protein (SMA), an early marker of smooth muscle differentiation, is detected at any axial level of the ureter, unlike in wild-type embryos where SMA is detected in the proximal ureter

• at the newborn stage, SMA is detected in the proximal ureter but, in contrast to wild-type controls, almost no SMA is detected in the distal-most part of the ureter, closest to the bladder

• in addition, mesenchymal cells in the distal ureter are not as condensed as those in wild-type controls

hydroureter ( J:79481 )

• newborn mice exhibit prominent hydroureter, usually more severe in the proximal region

short ureter ( J:79481 )

• at E14.5, ureter length is ~21% shorter than in wild-type controls

Allelic Composition	Itgb1^tm1Ross/Itgb1^tm1Ross Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm1Ross mutation (0 available); any Itgb1 mutation (60 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:149831 )

• ~5% of mice failed to survive either birth or the first week of life due to complete bilateral renal agenesis

• all others survived into adulthood (8 weeks), indicating at least one functioning kidney

renal/urinary system

increased kidney apoptosis ( J:149831 )

• a significant increase in apoptotic (TUNEL+) cells was observed in the cortex

• a significant increase in apoptotic (TUNEL+) cells was associated with the dilated tubules in the medulla

increased kidney cell proliferation ( J:149831 )

• a significant increase in proliferative (Ki67+) cells was noted in the cortex, probably associated with proximal tubular structures, but not in the medulla

abnormal urine homeostasis ( J:149831 )

• adult mice displayed an increased urinary AVP-to-creatinine ratio (as a surrogate for plasma AVP levels)

decreased urine osmolality ( J:149831 )

• adult mice exhibited a severe decrease in urine osmolarity relative to control mice

abnormal kidney morphology ( J:149831 )

• mice exhibited a wide range of kidney abnormalities ranging from bilateral agenesis to grossly normal-sized kidneys

• mice with polyuria and renal failure showed a severely disturbed kidney architecture

abnormal kidney collecting duct morphology ( J:149831 )

• adult renal medullary collecting ducts exhibited hypoplasia, increased apoptosis, dilation (ectasia) and cyst formation

dilated kidney collecting duct ( J:149831 )

• adult renal medullary collecting ducts exhibited ectasia

abnormal kidney cortex morphology ( J:149831 )

• in adult mice, normal renal cortex areas containing clustered glomeruli were separated by larger areas with multiple cystic structures, likely to be dilated cortical collecting ducts

• a significant increase in apoptotic (TUNEL+) cells was observed in the cortex

• a significant increase in proliferative (Ki67+) cells was noted in the cortex, probably associated with proximal tubular structures, but not in the medulla

abnormal kidney medulla morphology ( J:149831 )

• in adult mice, the renal medulla exhibited tubular ectasia

• a significant increase in apoptotic (TUNEL+) cells was associated with the dilated tubules in the medulla

kidney medulla cyst ( J:149831 )

• adult renal medullary collecting ducts exhibited cyst formation

kidney medulla hypoplasia ( J:149831 )

• late-stage developing kidneys displayed a reduced inner medulla size

small kidney ( J:149831 )

• at both 1 and 2 wks of age, mutant kidneys were smaller than control kidneys

decreased kidney weight ( J:149831 )

• at both 1 and 2 weeks of age

renal hypoplasia ( J:149831 )

• at E18-P1, eleven of 25 mice showed gross renal hypoplasia, with mutant kidneys being less than 2/3 of normal size

absent kidney ( J:149831 )

• 2 of 45 mice (~5%) displayed complete bilateral renal agenesis

single kidney ( J:149831 )

• at E18-P1, one of 25 mice displayed unilateral renal agenesis

abnormal renal filtration rate ( J:149831 )

• adult kidneys exhibited a reduced capacity to clear the contrast agent DPTA from blood

abnormal renal transport ( J:149831 )

• in adult mice, renal uptake of labeled PAH was reduced ~85% relative to that of control kidneys

isosthenuria ( J:149831 )

• mutant urine remained relatively isosmotic with blood plasma

kidney failure ( J:149831 )

• in mice with polyuria and severely disturbed kidney architecture

polyuria ( J:149831 )

• at 8 weeks of age, mice had >10 times the urine output seen in control mice

• water deprivation for 12 hrs failed to reduce the urine output, unlike in control mice

• polyuria is likely due to an inability to respond to AVP within the kidney

homeostasis/metabolism

increased blood urea nitrogen level ( J:149831 )

• adult mice displayed increased plasma urea levels

abnormal urine homeostasis ( J:149831 )

• adult mice displayed an increased urinary AVP-to-creatinine ratio (as a surrogate for plasma AVP levels)

decreased urine osmolality ( J:149831 )

• adult mice exhibited a severe decrease in urine osmolarity relative to control mice

hematopoietic system

decreased hematocrit ( J:149831 )

• adult mice displayed a significantly lower blood hematocrit than control mice (42% in vs. 52%)

cellular

increased kidney apoptosis ( J:149831 )

• a significant increase in apoptotic (TUNEL+) cells was observed in the cortex

• a significant increase in apoptotic (TUNEL+) cells was associated with the dilated tubules in the medulla

increased kidney cell proliferation ( J:149831 )

• a significant increase in proliferative (Ki67+) cells was noted in the cortex, probably associated with proximal tubular structures, but not in the medulla

growth/size/body

kidney medulla cyst ( J:149831 )

• adult renal medullary collecting ducts exhibited cyst formation

Allelic Composition	Lin7c^tm2Dsb/Lin7c^tm2Dsb Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7c^tm2Dsb mutation (0 available); any Lin7c mutation (17 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:134806 )

Allelic Composition	Spry1^tm1Jdli/Spry1^tm1Jdli Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:96485 )

• neonatal kidneys are highly disorganized as revealed by ectopic renal nodules

abnormal ureter morphology ( J:96485 )

• 11 of 15 newborn mice display ureter abnormalities (multiple ureters or hydoureter) similar to Spry1^tm1.1Jdli homozygotes

ectopic ureter ( J:96485 )

• extra ureters attach to the vas deferens in newborn males

hydroureter ( J:96485 )

Allelic Composition	Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1^tm2Ggg mutation (1 available); any Pkd1 mutation (154 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased kidney apoptosis ( J:171619 )

• apoptosis is increased in kidneys in P7 and P15 mice

increased kidney cell proliferation ( J:171619 )

• cell proliferation is increased in kidneys in both early and late stage of cystogenesis

polycystic kidney ( J:171619 )

• newborn mice exhibit microscopic kidney cysts derived from both cortical and medullary collecting ducts

• P7 kidneys have more and larger cysts, with less parenchyma compared to those in newborns

• by P15, mice present with huge bilateral masses on their flanks and kidneys are grossly cystic with very little normal renal parenchyma

• early and late stage of cystogenesis is associated with increased cell proliferation and increased Cux1 expression while late stage cystogenesis is associated with increased apoptosis and increased Cux1 expression

cellular

increased kidney apoptosis ( J:171619 )

• apoptosis is increased in kidneys in P7 and P15 mice

increased kidney cell proliferation ( J:171619 )

• cell proliferation is increased in kidneys in both early and late stage of cystogenesis

homeostasis/metabolism

increased blood urea nitrogen level ( J:171619 )

• BUN levels are increased at P7 and P15

growth/size/body

polycystic kidney ( J:171619 )

• newborn mice exhibit microscopic kidney cysts derived from both cortical and medullary collecting ducts

• P7 kidneys have more and larger cysts, with less parenchyma compared to those in newborns

• by P15, mice present with huge bilateral masses on their flanks and kidneys are grossly cystic with very little normal renal parenchyma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 1		DOID:0110858	OMIM:173900	J:171619

Allelic Composition	Crkl^{tm1c(EUCOMM)Hmgu}/Crkl^{tm1c(EUCOMM)Hmgu} Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkl^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Crkl mutation (17 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:348704 )

• 1 out of 10 fetuses exhibit exencephaly

Allelic Composition	Ift20^tm1.1Gjp/Ift20^tm1.1Gjp Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift20^tm1.1Gjp mutation (1 available); any Ift20 mutation (21 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased kidney cell proliferation ( J:141071 )

• by P23, collecting duct cells lacking cilia show increased rates of proliferation

abnormal kidney morphology ( J:141071 )

• by P23 most of the kidney is replaced by collecting duct epithelium, fluid filled cysts, and fibrotic material

absent kidney epithelial cell primary cilium ( J:141071 )

• at E18 collecting duct epithelial cells almost completely lack cilia

kidney cyst ( J:141071 )

• cystic expansion of the collecting ducts

• cells lining cysts lack primary cilia

• cells lining cysts may be flat with prominent microvilli or domed with less pronounced microvilli

enlarged kidney ( J:141071 )

• progressive bilateral kidney enlargement beginning by P10

increased kidney weight ( J:141071 )

• by P23, kidney weight is about 10 times that of controls

abnormal kidney collecting duct epithelium morphology ( J:141071 )

• at E18 collecting duct epithelial cells almost completely lack cilia

• at P5 in non-dilated tubules, mitotic spindle orientation is randomized rather than being parallel to the long axis of the tubule

• at P5 the centrosome remains at the apical end of the cell but can be located anywhere from the lateral junction to the center of the cell rather than at the center of the cell

dilated kidney collecting duct ( J:141071 )

• dilation is first seen at P5

renal interstitial fibrosis ( J:141071 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:141071 )

• about 3 times higher than in controls

cellular

absent kidney epithelial cell primary cilium ( J:141071 )

• at E18 collecting duct epithelial cells almost completely lack cilia

increased kidney cell proliferation ( J:141071 )

• by P23, collecting duct cells lacking cilia show increased rates of proliferation

growth/size/body

kidney cyst ( J:141071 )

• cystic expansion of the collecting ducts

• cells lining cysts lack primary cilia

• cells lining cysts may be flat with prominent microvilli or domed with less pronounced microvilli

enlarged kidney ( J:141071 )

• progressive bilateral kidney enlargement beginning by P10

increased kidney weight ( J:141071 )

• by P23, kidney weight is about 10 times that of controls

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/? Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt7b^tm2.1Amc mutation (0 available); any Wnt7b mutation (17 available)
Wnt7b^tm2Amc mutation (1 available); any Wnt7b mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

dilated kidney collecting duct ( J:142685 )

• at E15.5 the collecting ducts are dilated and branch points are less evident

Allelic Composition	Lhx1^tm2.1Bhr/Lhx1^tm1Tmj Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Lhx1^tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:98831 )

• hypoplastic metanephroi with reduced number of glomeruli

• however, morphologically normal medulla and glomeruli

small metanephros ( J:98831 )

• neonates had small metanephroi that were functional at birth

hydronephrosis ( J:98831 )

• observed in 40% of mutants

renal hypoplasia ( J:98831 )

decreased nephron number ( J:98831 )

• greatly reduced numbers of developing nephrons at birth

abnormal ureter development ( J:98831 )

• the distal ureter was closed in both sexes

ectopic ureter ( J:98831 )

• the distal ureter ended abnormally in the uterus in some females

hydroureter ( J:98831 )

• observed in 40% of mutants

abnormal ureteric bud morphology ( J:98831 )

• delayed induction of the ureteric bud

reproductive system

uterus hypoplasia ( J:98831 )

• 57.1% of mutant females had completely or partially absent uteri with residual uterine tissue discontinuously present

• posterior uterus was more frequently absent compared to the anterior region

absent uterus ( J:98831 )

• 57.1% of mutant females had completely or partially absent uteri

absent epididymis ( J:98831 )

• absent epididymis in all mutant males

absent vas deferens ( J:98831 )

embryo

abnormal mesonephros morphology ( J:98831 )

• loss of caudal mesonephric tubules; however, the cranial mesonephros was present

abnormal Mullerian duct morphology ( J:98831 )

• exhibited Mullerian duct aplasia, impaired posterior elongation of the Mullerian duct and Mullerian duct degeneration adjacent to where the Wolffian duct was lost

Mullerian duct degeneration ( J:98831 )

absent Mullerian ducts ( J:98831 )

rudimentary Mullerian ducts ( J:98831 )

Wolffian duct degeneration ( J:98831 )

• degeneration of the nephric (Wolffian) duct epithelium that resulted in the absence of most parts of the reproductive tract in all mutant males, except for some residual tissue

Allelic Composition	Scnn1a^tm1.1Hum/Scnn1a^tm1.1Hum Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnn1a^tm1.1Hum mutation (1 available); any Scnn1a mutation (28 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal transport ( J:161474 )

• when mice are fed a normal sodium diet, cortical collecting ducts exhibit no significant sodium, chloride, or potassium ion transport unlike wild-type ducts from similarly treated wild-type mice

• when mice are fed a sodium-depleted diet, cortical collecting ducts absorb sodium without forming a lumen-negative transepithelial voltage unlike ducts from similarly treated wild-type mice

Allelic Composition	Aqp2^tm1Nlsn/Aqp2^tm1Nlsn Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp2^tm1Nlsn mutation (0 available); any Aqp2 mutation (17 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:108291 )

• partial penetrance

renal/urinary system

decreased urine osmolality ( J:108291 )

• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice

• water deprivation does not increase urine osmolality

kidney papillary atrophy ( J:108291 )

• variable progressive papillary atrophy in those that survive past weaning

hydronephrosis ( J:108291 )

• variable progressive hydronephrosis in those that survive past weaning

polyuria ( J:108291 )

• about a 10-fold increase in urine output

• water deprivation results in only a marginal decrease in urine output

homeostasis/metabolism

decreased urine osmolality ( J:108291 )

• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice

• water deprivation does not increase urine osmolality

Allelic Composition	Gt(ROSA)26Sor^{tm1(RARA*)Clmd}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(RARA*)Clmd} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• renal hypoplasia with a 50-80% reduction in branch numbers at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• 50-80% reduction in branch numbers at E14

Allelic Composition	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• severe renal hypoplasia with reduced branching at E14

absent kidney ( J:157254 )

• renal agenesis at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• barely begin to branch at E11

• severe renal hypoplasia with reduced branching at E14

small ureteric bud ( J:157254 )

• smaller ureteric bud at E10.5 than in normal embryos

Allelic Composition	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129/SvEv * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:157254 )

• few ureteric bud branches or nephrons and severe patterning abnormalities at E14

renal hypoplasia ( J:157254 )

• at E14 the kidneys are greatly reduced in size than normal

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• few ureteric bud branches at E14

Allelic Composition	Wnt7b^tm2Amc/Wnt7b^tm2.1Amc Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt7b^tm2.1Amc mutation (0 available); any Wnt7b mutation (17 available)
Wnt7b^tm2Amc mutation (1 available); any Wnt7b mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:142685 )

• survive to P11 - P12

renal/urinary system

decreased urine osmolality ( J:142685 )

• at P10, urine osmolality is 56% that of controls

abnormal kidney morphology ( J:142685 )

• at P11 - P12 kidneys are grossly abnormal

absent kidney medulla ( J:142685 )

• absent at P10

kidney failure ( J:142685 )

• by P11 - P12 kidneys are physiologically incompetent

homeostasis/metabolism

decreased urine osmolality ( J:142685 )

• at P10, urine osmolality is 56% that of controls

Allelic Composition	Gfra1^tm2Jmi/Gfra1^tm3Jmi Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1^tm2Jmi mutation (0 available); any Gfra1 mutation (33 available)
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:199323 )

• at P0, most have bilateral kidney agenesis/aplasia (16/20)

single kidney ( J:199323 )

• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter

large ureter ( J:199323 )

• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Kidney agenesis in Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Hoxb7-cre)13Amc/0 mice

renal/urinary system

abnormal kidney development ( J:160547 )

• mice exhit both uni- and bilateral kidney agenesis, similar to that observed in Lrp4^tm2Her homozygotes

• however, formation of the Wolffian duct and distal ureters as well as bladder and adrenal glands remain intact

absent kidney ( J:160547 )

single kidney ( J:160547 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:100575 )

N	• when the Wnt1:GFP fusion protein is expressed in the Wolffian duct, embryos exhibit normal mesonephric and metanephric tubule induction, as well as caudal extension of the Mullerian duct

Allelic Composition	Cyp2c23^tm1.1Jhc/Cyp2c23^tm1.1Jhc Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp2c23^tm1.1Jhc mutation (0 available); any Cyp2c23 mutation (28 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:213555 )

• mutant mice fed a high K+ (5% KCl) diet for 3 days show a significantly increased body weight on HK day 2, unlike wild-type controls where increased K+ intake has no effect on body weight

cardiovascular system

increased systemic arterial systolic blood pressure ( J:213555 )

• mutant mice fed a high K+ (5% KCl) diet display significantly increased systolic BP and remain hypertensive for 3 days during increased K+ intake, unlike wild-type controls

• addition of amiloride (an epithelial Na+ channel inhibitor) in drinking water abolishes high K+ intake-induced hypertension and decreases systolic BP from 146 +/- 5 to 117 +/- 3 mmHg, unlike in wild-type controls where amiloride has no effect on BP

• mutant mice fed a high-salt (4% NaCl) diet for 3 days show no significant differences in mean systolic BP relative to wild-type controls

• no differences in mean systolic BP are observed under normal salt or normal K+ (1.0% KCl) conditions relative to wild-type controls

renal/urinary system

decreased urine sodium level ( J:213555 )

• mutant mice fed a high K+ (5% KCl) diet display significantly decreased Na+ excretion relative to mutant mice fed a normal K+ (1.0% KCl) diet, unlike wild-type controls

• however, mutant mice exhibit no differences in Na+ intake when fed a 5% KCl diet or a normal (1.0% KCl) diet

abnormal kidney physiology ( J:213555 )

• 10 uM of arachidonic acid (AA) fails to inhibit apical epithelial Na+ channel (ENaC) activity in the cortical collecting duct (CCD) of mutant mice fed a high K+ (5% KCl) diet, unlike in wild-type controls where channel activity (NPo) is decreased from 1.2 +/- 0.2 to 0.3 +/- 0.1

• however, addition of 100 nM 11,12-epoxyeicosatrienoic acid (11,12-EET) is still able to inhibit ENaC in the CCD of mutant mice fed a high K+ (5% KCl) diet, with NPo reduced from 2.5 +/- 0.4 to 0.2 +/- 0.1

homeostasis/metabolism

decreased urine sodium level ( J:213555 )

• mutant mice fed a high K+ (5% KCl) diet display significantly decreased Na+ excretion relative to mutant mice fed a normal K+ (1.0% KCl) diet, unlike wild-type controls

• however, mutant mice exhibit no differences in Na+ intake when fed a 5% KCl diet or a normal (1.0% KCl) diet

Allelic Composition	Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1^tm3Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205755 )

N	• mice are obtained at a Mendelian frequency and survive over 1 year

renal/urinary system

renal/urinary system phenotype ( J:205755 )

N	• mice exhibit normal kidneys

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