About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd59atm1Song
targeted mutation 1, Wen-Chao Song
MGI:2675293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd59atm1Song/Cd59atm1Song involves: 129S6/SvEvTac MGI:2675294
cx2
 		Cd59atm1Song/Cd59atm1Song
Cd55tm1Song/Cd55tm1Song 		involves: 129S6/SvEvTac * C57BL/6 MGI:3581707


Genotype
MGI:2675294
hm1
Allelic
Composition		 Cd59atm1Song/Cd59atm1Song
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd59atm1Song mutation (2 available); any Cd59a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal complement pathway ( J:76578 )
• erythrocytes are more susceptible to autologous and heterologous MAC lysis under conditions of induced complement activation by antibodies or cobra venom factor (CVF)
• however, erythrocytes have a normal lifespan in vivo and mice do not develop spontaneous hemolytic anemia




Genotype
MGI:3581707
cx2
Allelic
Composition		 Cd59atm1Song/Cd59atm1Song
Cd55tm1Song/Cd55tm1Song
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd55tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cd59atm1Song mutation (2 available); any Cd59a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal complement pathway ( J:76578 )
• in vitro, double-mutant erythrocytes display a significantly increased sensitivity to antibody-induced autologous and heterologous complement lysis by membrane attack complex (MAC) relative to wild-type or single mutant erythrocytes

hematopoietic system
hematopoietic system phenotype ( J:76578 )
N
• despite enhanced sensitivity to antibody-induced complement lysis in vitro, double mutants develop no signs of hemolytic anemia and are resistant to spontaneous complement attack in vivo
• total peripheral erythrocyte counts, blood hemoglobin concentrations, and the average reticulocyte count remain unaffected; transfusion experiments confirm normal erythrocyte lifespans in vivo




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory