Phenotypes associated with this allele

• Allele Symbol: Lrig1^tm1Ita
• Allele Name: targeted mutation 1, Sato Itami
• Allele ID: MGI:2675424
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrig1^tm1Ita/Lrig1^tm1Ita	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2675429

Genotype
MGI:2675429

hm1

• Allelic Composition: Lrig1^tm1Ita/Lrig1^tm1Ita
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal facial morphology ( J:77286 )

• homozygotes display hair loss with scales and erosion in the facial area

limbs/digits/tail

thick tail ( J:77286 )

• mutant tails display a knot-like thickening with scales

nervous system

nervous system phenotype ( J:77286 )

N • contrary to expectation, homozygotes show no apparent defects in neural tissues

integument

increased keratinocyte proliferation ( J:77286 )

• affected tail skin displays hyperproliferative keratinocytes in the epidermal basal cell layer, as revealed by Ki67 staining

alopecia ( J:77286 )

• homozygotes display hair loss in the facial area

abnormal skin morphology ( J:77286 )

• at the age of 3 weeks to 4 months homozygotes, but not wild-type mice, develop skin defects on the tail, facial area and ear

• however, no skin changes are observed in the trunk and feet

abnormal keratinocyte differentiation ( J:77286 )

• lesional keratinocytes are hyperproliferative and exhibit abnormal terminal differentiation

hyperkeratosis ( J:77286 )

• affected tail skin displays hyperkeratosis

parakeratosis ( J:77286 )

• affected tail skin displays parakeratosis

epidermal hyperplasia ( J:77286 )

• affected tail skin displays epidermal hyperplasia

thick epidermis ( J:77286 )

• mildly affected homozygotes display only a thickened epidermis with no inflammatory cell infiltration

scaly skin ( J:77286 )

• the affected facial and tail skin displays scales

psoriasis ( J:77286 )

• affected tail skin displays psoriasiform epidermal hyperplasia with hyperkeratosis and parakeratosis, neutrophil influx, and subcorneal pustules that resemble "Munro's microabscesses"; however, no infiltrations of T lymphocytes or increased dermal capillarization are observed

• psoriasiform epidermal changes can be reversed by treatment with anti-psoriatic drugs (e.g. steroid and vitamin D3 analog ointments)

cellular

abnormal keratinocyte differentiation ( J:77286 )

• lesional keratinocytes are hyperproliferative and exhibit abnormal terminal differentiation

increased keratinocyte proliferation ( J:77286 )

• affected tail skin displays hyperproliferative keratinocytes in the epidermal basal cell layer, as revealed by Ki67 staining

growth/size/body

abnormal facial morphology ( J:77286 )

• homozygotes display hair loss with scales and erosion in the facial area