All Phenotypes Ccne1<tm1Pisc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccne1^tm1Pisc/Ccne1^tm1Pisc	involves: 129S2/SvPas	MGI:2675486
cx2	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Boa/Ccne2^tm1Boa	involves: 129/Sv * C57BL/6	MGI:2677716
cx3	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Pisc/Ccne2⁺	involves: 129S2/SvPas	MGI:2675490
cx4	Ccne1^tm1Pisc/Ccne1⁺ Ccne2^tm1Pisc/Ccne2^tm1Pisc	involves: 129S2/SvPas	MGI:2675491
cx5	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc	involves: 129S2/SvPas	MGI:2675493

Allelic Composition	Ccne1^tm1Pisc/Ccne1^tm1Pisc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm1Pisc mutation (0 available); any Ccne1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85224 )

Allelic Composition	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Boa/Ccne2^tm1Boa
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2^tm1Boa mutation (0 available); any Ccne2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:85497 )

• most are dead at E11.5

• 2 of 10 still had beating hearts at E11.5

• most double homozygotes were still alive at E10.5

cardiovascular system

abnormal vasculogenesis ( J:85497 )

• cranial vascularization at E10.5 like that typical at E9.5

abnormal vitelline vasculature morphology ( J:85497 )

• 60% showing poorly vascularized yolk sac at E11.5

embryo

embryonic growth retardation ( J:85497 )

abnormal extraembryonic tissue morphology ( J:85497 )

abnormal vitelline vasculature morphology ( J:85497 )

• 60% showing poorly vascularized yolk sac at E11.5

abnormal trophoblast layer morphology ( J:85497 )

• reduced DNA content in trophoblast giant cells

• failure of endoreplication, few cells reach a ploidy of 8N

growth/size/body

abnormal embryonic growth/weight/body size ( J:85497 )

• no obvious morphological defects at E9.5-11.5

embryonic growth retardation ( J:85497 )

Allelic Composition	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Pisc/Ccne2⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2^tm1Pisc mutation (0 available); any Ccne2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85224 )

Allelic Composition	Ccne1^tm1Pisc/Ccne1⁺ Ccne2^tm1Pisc/Ccne2^tm1Pisc
Genetic Background	involves: 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

testis hypoplasia ( J:85224 )

reproductive system

abnormal reproductive system morphology ( J:85224 )

• phenotype like that of homozygous Ccne2^tm1Pisc but more severe

testis hypoplasia ( J:85224 )

abnormal fertility/fecundity ( J:85224 )

• phenotype like that of homozygous Ccne2^tm1Pisc but more severe

reduced male fertility ( J:85224 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:85224 )

• expected number of homozygotes through E10.25

• only 50% of expected number of homozygotes found at E10.75

• no live double homozygotes after E11.5

cardiovascular system

abnormal cardiovascular system morphology ( J:85224 )

• observed in embryos rescued by tetraploid complementation

abnormal aortic arch development ( J:85224 )

• abnormal patterning of the aortic arch, possibly resulting from a defect in neural crest migration

double outlet right ventricle ( J:85224 )

ostium primum atrial septal defect ( J:85224 )

• observed in embryos rescued by tetraploid complementation

atrioventricular septal defect ( J:85224 )

ventricular septal defect ( J:85224 )

• observed in embryos rescued by tetraploid complementation

embryo

decreased embryo size ( J:85224 )

• normal morphogenesis and no pathological lesions despite growth retardation at E10.75

abnormal extraembryonic tissue morphology ( J:85224 )

abnormal placenta morphology ( J:85224 )

• partial rescue of embryonic lethality by tetraploid complementation proves that a problem exists in the placenta

abnormal trophoblast giant cell morphology ( J:85224 )

• layer of trophoblast giant cells reduced or absent

• greatly reduced DNA content relative to expectation

growth/size/body

decreased embryo size ( J:85224 )

• normal morphogenesis and no pathological lesions despite growth retardation at E10.75

hematopoietic system

abnormal definitive hematopoiesis ( J:85224 )

• observed in embryos rescued by tetraploid complementation

abnormal thrombopoiesis ( J:85224 )

• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation

immune system

abnormal thrombopoiesis ( J:85224 )

• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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