All Phenotypes Nfkb2<tm1Rsch> MGI Mouse

increased plasmacytoid dendritic cell number ( J:77049 )

• lymphoid dendritic cells are increased in the follicle-associated epithelium (FAE)

decreased dendritic cell number ( J:77049 )

• large decrease of immature follicular dendritic cells in Peyer's patches

• CD11b^-CD8^- dendritic cells are reduced in Peyer's patches

• reduction of B cells in Peyer's patches

abnormal myeloid dendritic cell morphology ( J:77049 )

• myeloid dendritic cells are mainly restricted to the small B-cell areas and are widely distributed in low numbers in the enlarged T-cell regions of Peyer's patches instead of being predominately located in the subepithelial dome

decreased myeloid dendritic cell number ( J:77049 )

• myeloid dendritic cells are reduced in Peyer's patches

abnormal Peyer's patch morphology ( J:77049 )

• reduced B220⁺ B cells/CD3⁺ T cell ratio, such that Peyer's patches consist mainly of T cells

• Peyer's patches are macroscopically undetectable, however structures lacking follicles and germinal centers are detected

• lack a well-organized subepithelial dome (SED) region

abnormal Peyer's patch follicle morphology ( J:77049 )

• defective follicular organization with no clear follicle demarcations

• lymphoid dendritic cells and CD8⁺ T cells are increased in the follicle-associated epithelium

• 3-5 fold increase of M cells in the follicle-associated epithelium

abnormal Peyer's patch T cell area morphology ( J:77049 )

• increase of CD8⁺ T cells in the T-cell region

abnormal Peyer's patch germinal center morphology ( J:77049 )

• complete lack of germinal centers with a mature follicular dendritic cell network

small Peyer's patches ( J:77049 )

• Peyer's patches are small in size and show no dome area and no clear demarcations to the gut mucosa