Phenotypes associated with this allele

• Allele Symbol: Gas6^tm1Pec
• Allele Name: targeted mutation 1, Peter Carmeliet
• Allele ID: MGI:2675495
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gas6^tm1Pec/Gas6^tm1Pec	involves: 129S1/Sv * 129X1/SvJ	MGI:2675497

Genotype
MGI:2675497

hm1

• Allelic Composition: Gas6^tm1Pec/Gas6^tm1Pec
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:77462 )

• platelets fail to aggregrate in response to low concentrations of ADP, collagen or U46619 (TXA2 analogue)

• although thrombin stimulates platelet aggregation in mutants, the platelets are abnormally loosely packed, display fewer and smaller contact sites and are incompletely degranulated

abnormal platelet dense granule physiology ( J:77462 )

• secretion of dense granule stores, as measured by ATP release, is significantly impaired in platelets

decreased susceptibility to induced thrombosis ( J:77462 )

• mice are protected against the development of induced arterial and venous thrombosis, but do not suffer spontaneous or trauma-induced bleeding

• resistance to thrombosis is not due to increased thrombolysis

cardiovascular system

increased vascular permeability ( J:198769 )

• in the brain and liver

vision/eye

vision/eye phenotype ( J:116526 )

N • retinas appear normal with no photoreceptor degeneration

hematopoietic system

decreased platelet aggregation ( J:77462 )

• platelets fail to aggregrate in response to low concentrations of ADP, collagen or U46619 (TXA2 analogue)

• although thrombin stimulates platelet aggregation in mutants, the platelets are abnormally loosely packed, display fewer and smaller contact sites and are incompletely degranulated

abnormal platelet dense granule physiology ( J:77462 )

• secretion of dense granule stores, as measured by ATP release, is significantly impaired in platelets