All Phenotypes Dnase2b<tm1Osa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnase2b^tm1Osa
targeted mutation 1, Shigekazu Nagata
MGI:2675502

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnase2b^tm1Osa/Dnase2b^tm1Osa	Not Specified	MGI:2675506

Allelic Composition	Dnase2b^tm1Osa/Dnase2b^tm1Osa
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase2b^tm1Osa mutation (1 available); any Dnase2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:85215 )

• cataracts of the nucleus lentis caused by undigested DNA left in the lens

• eyeballs are of normal morphology, with well-differentiated mature lens fiber cells

abnormal eye electrophysiology ( J:85215 )

• electroretinogram recordings under dark-adapted conditions shows that responses to the light flash are severely reduced

abnormal vision ( J:85215 )

• reduction in response to light due to cataract formation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:85215

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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