All Phenotypes Cdk2<tm1Sgo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk2^tm1Sgo
targeted mutation 1, Sagrario Ortega
MGI:2675585

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk2^tm1Sgo/Cdk2^tm1Sgo	involves: 129/Sv * CD-1	MGI:2675622
cn2	Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844195
cx3	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759575
cx4	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759576
cx5	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3723204
cx6	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3054096

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo
Genetic Background	involves: 129/Sv * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:85230 )

• oviducts and uterus normal

absent corpus luteum ( J:85230 )

absent ovarian follicles ( J:85230 )

ovary atrophy ( J:85230 )

• by day 120 ovaries are atrophic (15-20% normal size)

• frequently find epithelium lined cysts replacing ovarian tissue

abnormal gametogenesis ( J:85230 )

• failure of both oogenesis and spermatogenesis

abnormal oocyte morphology ( J:85230 )

• ovaries normal through E17.5 when oocytes reach pachytene stage of meiosis

• by day 1 after birth when oocytes should be in late diplotene stage, few oocytes are left and apoptosis is occurring

abnormal meiosis ( J:85230 )

• failure of chromosome pairing

• meiosis fails to proceed past the pachytene stage of prophase I

abnormal spermiogenesis ( J:85230 )

• testes normal to day 15 when germ cells are tetraploid primary sperm cells

• by day 20, an absence of expected round spermatids

• apoptosis of spermatocytes occuring at day 20

abnormal male reproductive system morphology ( J:85230 )

abnormal seminiferous tubule morphology ( J:85230 )

• normal proliferation of spermatogonia through day 30 when seminiferous tubules are almost completely depleted of germ cells

testicular atrophy ( J:85230 )

• by day 120, testes are atrophic (20% normal size)

• normal levels of spermatogonia, Sertoli and Leydig cells

• few primary spermatocytes

• no post meiotic cells

abnormal fertility/fecundity ( J:85230 )

infertility ( J:85230 )

• both sexes were totally sterile

endocrine/exocrine glands

absent corpus luteum ( J:85230 )

absent ovarian follicles ( J:85230 )

ovary atrophy ( J:85230 )

• by day 120 ovaries are atrophic (15-20% normal size)

• frequently find epithelium lined cysts replacing ovarian tissue

abnormal seminiferous tubule morphology ( J:85230 )

• normal proliferation of spermatogonia through day 30 when seminiferous tubules are almost completely depleted of germ cells

testicular atrophy ( J:85230 )

• by day 120, testes are atrophic (20% normal size)

• normal levels of spermatogonia, Sertoli and Leydig cells

• few primary spermatocytes

• no post meiotic cells

cellular

abnormal oocyte morphology ( J:85230 )

• ovaries normal through E17.5 when oocytes reach pachytene stage of meiosis

• by day 1 after birth when oocytes should be in late diplotene stage, few oocytes are left and apoptosis is occurring

abnormal meiosis ( J:85230 )

• failure of chromosome pairing

• meiosis fails to proceed past the pachytene stage of prophase I

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (84 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161780 )

• mice treated tamoxifen at weaning exhibit an increase in lifespan of 8 weeks (42 weeks) compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} littermates (34 weeks)

neoplasm

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice exhibit reduced tumor burden compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125217 )

• although mice move and ingest milk at birth, they die within 24 hours due to cardiac failure

cardiovascular system

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

thin ventricular wall ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

congestive heart failure ( J:125217 )

• mice die within 24 hours of birth due to cardiac failure

liver/biliary system

liver hypoplasia ( J:125217 )

• fetal livers contain 60% of the cells found in wild-type livers

• however, this reduction is proportional to the reduction in overall size of embryos

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

abnormal liver physiology ( J:125217 )

• mice suffer from congestive livers

hematopoietic system

abnormal definitive hematopoiesis ( J:125217 )

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

• however, the number of granulocyte-macrophage progenitors, common myeloid progenitors and megakaryocyte-erythroid progenitor cells are normal

decreased erythrocyte cell number ( J:125217 )

• at E17.5, mice have a small decrease in red blood cell (RBC) number (1.27x10⁶+/-0.14 RBC per mm³ compared to 1.45x10⁶+/-0.11 RBC per mm³ in wild-type mice)

• however, this decrease does not affect viability

cellular

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal cell cycle ( J:125217 )

• primary mouse embryonic fibroblast cells are delayed in the percent of cells entering into S phase but eventually equalize with wild-type cells

decreased fibroblast proliferation ( J:125217 )

• proliferation of mouse embryonic fibroblast (MEF) cells is decreased relative to wild-type MEFs

growth/size/body

decreased body weight ( J:125217 )

• at birth mice weigh 25% to 40% less than wild-type mice

muscle

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

Allelic Composition	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:125217 )

• 60% of mice do not complete embryonic development

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk4^tm1Bbd mutation (1 available); any Cdk4 mutation (58 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

growth/size/body

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

cardiovascular system

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

thin ventricular wall ( J:124678 )

• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes

cellular

decreased cell proliferation ( J:124678 )

• proliferation of mouse embryonic fibroblast cells is partially compromised

• exiting quiescence following serum treatment is delayed

liver/biliary system

liver hypoplasia ( J:124678 )

• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:124678 )

• common myeloid progenitor cells are reduced 8-fold in number

muscle

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

embryo

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:92529 )

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

abnormal spermatogenesis ( J:92529 )

• marked defects in spermatogenesis seen

infertility ( J:92529 )

• double homozygotes are sterile

cellular

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

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