Phenotypes associated with this allele

• Allele Symbol: Synpo^tm1Mndl
• Allele Name: targeted mutation 1, Peter Mundel
• Allele ID: MGI:2675703
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Synpo^tm1Mndl/Synpo^tm1Mndl	involves: 129P2/OlaHsd * C57BL/6	MGI:2675736

Genotype
MGI:2675736

hm1

• Allelic Composition: Synpo^tm1Mndl/Synpo^tm1Mndl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:85310 )

N • normal brain cytoarchitecture

abnormal telencephalon development ( J:85310 )

• telencephalic neurons lack spine apparatus but there was no loss of spines

reduced long-term potentiation ( J:85310 )

• both early and late induction rates were reduced using either tetanus or theta burst stimulation

• basal synaptic transmission normal

behavior/neurological

abnormal spatial learning ( J:85310 )

• impaired spatial learning as determined using a radial arm maze

decreased anxiety-related response ( J:85310 )

• less anxiety on an elevated plus maze

decreased locomotor activity ( J:85310 )

• decreased horizontal activity

• vertical activity normal

renal/urinary system

renal/urinary system phenotype ( J:85310 )

N • fine structure of kidney podocytes was normal by electron microscopy

N • kidney function was normal based on urinary protein excretion analysis