Phenotypes associated with this allele

• Allele Symbol: Drd2^tm2Ebo
• Allele Name: targeted mutation 2, Emiliana Borrelli
• Allele ID: MGI:2675755
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd2^tm2Ebo/Drd2^tm2Ebo	involves: 129S2/SvPas * C57BL/6	MGI:3614880

Genotype
MGI:3614880

hm1

• Allelic Composition: Drd2^tm2Ebo/Drd2^tm2Ebo
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:77277 )

N • homozygotes show no significant differences in primitive reflexes, spontaneous locomotor behavior or locomotor activity in a novel cage and in the open field relative to wild-type mice

enhanced behavioral response to xenobiotic ( J:77277 )

• in response to a low dose of quinpirole (a D2-like specific agonist), homozygotes display a greater reduction in locomotor activity than wild-type mice, indicating that preserved D2R-mediated presynaptic function is mediated by the short isoform of the receptor

impaired behavioral response to xenobiotic ( J:77277 )

• homozygotes fail to exhibit a significant increase in locomotion in response to mixed D1/D2 dopaminergic agonists (apomorphine and SKF82958) or full D1 agonists (SKF81297), indicating significantly reduced postsynaptic responses to dopaminergic agonists and an inhibitory effect of the short isoform on D1R-mediated responses

• homozygotes fail to exhibit significant induction of catalepsy in response to haloperidol (a D2-like antagonist and antipsychotic drug), despite a normal haloperidol-induced increase of striatal dopamine levels in mutant mice; in contrast, SCH 23390 (a D1R antagonist) is still able to produce catalepsy in mutant mice