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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gp6tm1Ware
targeted mutation 1, Jerry Ware
MGI:2675830
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gp6tm1Ware/Gp6tm1Ware involves: Black Swiss MGI:2675842
cx2
 		Gp6tm1Ware/Gp6+
P3h2tm1Hpb/P3h2tm1Hpb 		involves: 129 * Black Swiss * C57BL/6J MGI:5585632
cx3
 		Gp6tm1Ware/Gp6tm1Ware
P3h2tm1Hpb/P3h2tm1Hpb 		involves: 129 * Black Swiss * C57BL/6J MGI:5585633
cx4
 		Mpig6btm1.1Arte/Mpig6btm1.1Arte
Gp6tm1Ware/Gp6tm1Ware 		involves: C57BL/6 * C57BL/6NTac MGI:5512897


Genotype
MGI:2675842
hm1
Allelic
Composition		 Gp6tm1Ware/Gp6tm1Ware
Genetic
Background		 involves: Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp6tm1Ware mutation (1 available); any Gp6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet activation ( J:85315 )
• failure of platelets to activate after interacting with type I collagen
decreased platelet aggregation ( J:85315 )
• platelets fail to aggregate

homeostasis/metabolism
abnormal blood coagulation ( J:85315 )
• contrary to expectation, no effect on tail bleeding times was observed
• platelets fail to take part in thrombus formation
abnormal platelet activation ( J:85315 )
• failure of platelets to activate after interacting with type I collagen
decreased platelet aggregation ( J:85315 )
• platelets fail to aggregate




Genotype
MGI:5585632
cx2
Allelic
Composition		 Gp6tm1Ware/Gp6+
P3h2tm1Hpb/P3h2tm1Hpb
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp6tm1Ware mutation (1 available); any Gp6 mutation (19 available)
P3h2tm1Hpb mutation (0 available); any P3h2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:206377 )
• although present at E8.5, no mice are present at birth




Genotype
MGI:5585633
cx3
Allelic
Composition		 Gp6tm1Ware/Gp6tm1Ware
P3h2tm1Hpb/P3h2tm1Hpb
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp6tm1Ware mutation (1 available); any Gp6 mutation (19 available)
P3h2tm1Hpb mutation (0 available); any P3h2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:206377 )
N
• mice are born in expected Mendelian ratios and survive to adulthood




Genotype
MGI:5512897
cx4
Allelic
Composition		 Mpig6btm1.1Arte/Mpig6btm1.1Arte
Gp6tm1Ware/Gp6tm1Ware
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp6tm1Ware mutation (1 available); any Gp6 mutation (19 available)
Mpig6btm1.1Arte mutation (0 available); any Mpig6b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:201266 )
• not as severe as in AU023871tm1.1Arte homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory