Analysis Tools|
Allele Symbol Allele Name Allele ID |
Badtm1Sjk targeted mutation 1, Stanley J Korsmeyer MGI:2675966 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2 days after neonatal hypoxia-ischemia (HI) injury, ispsilateral hippocampal area loss (10.3%) is half of that seen in wild-type mice (21%) after HI
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• reactive gliosis is significantly decreased in hippocampi of mutants 2 days after neonatal HI compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased death rate due to malignancies over a 2 year period
• 80% survive past 18 months as compared to 100% for wild-type mice
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• other tumor types (non lymphomas) occur in smaller numbers
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• about 20% develop diffuse large cell type lymphomas involving spleen and lymph nodes
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• usually germinal center B cell lymphomas
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• prominent multinucleated giant cells in seminiferous tubules
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• after irradiation at 4 weeks of age early T-cell lymphomas and later B-cell lymphomas
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• epithelial cells and embryonic fibroblasts with increased resistance to apoptosis from various stimuli
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• males were fertile despite abnormalities
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• normal IgM production but reduced IgG after lipopolysaccharide stimulation
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• a modest delay in the course of death among thymocytes exposed to gamma radiation
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• prominent multinucleated giant cells in seminiferous tubules
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• males were fertile despite abnormalities
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• normal IgM production but reduced IgG after lipopolysaccharide stimulation
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• a modest delay in the course of death among thymocytes exposed to gamma radiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• higher number of islets on a high fat diet
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• reduced sensitivity to apoptosis
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• isolated islet cells require more glucose to induce insulin release equivalent to that of controls
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• isolated islet cells require more glucose to induce insulin release equivalent to that of controls
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• resistance to hyperglycemia induced by a high fat diet
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• elevated blood insulin levels on a high fat diet
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| N |
• no abnormalities are detected in T cell numbers after HSV-1 infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after a 4 h fast, mice exhibit increased blood glucose levels as in mice with the transgene alone
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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