Phenotypes associated with this allele

• Allele Symbol: Esam^tm1Tq
• Allele Name: targeted mutation 1, Thomas Quertermous
• Allele ID: MGI:2675994
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esam^tm1Tq/Esam^tm1Tq	B6.129S6-Esam^tm1Tq	MGI:2675995

Genotype
MGI:2675995

hm1

• Allelic Composition: Esam^tm1Tq/Esam^tm1Tq
• Genetic Background: B6.129S6-Esam^tm1Tq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:85314 )

• mutants exhibit less neovascularization in matrigel plug assays than wild-type mice

• mutant endothelial cells exhibit less in vitro tube formation and a decrease in migration in response to basic fibroblast growth factor

• decrease in vascular density and size of tumors arising from injected tumor cell lines, relative to controls

growth/size/body

decreased body weight ( J:85314 )

• 15% reduction in body weight relative to wild-type

neoplasm

decreased tumor incidence ( J:85314 )

• mutants injected with melanoma and Lewis lung carcinoma cells show smaller tumor volumes, delayed growth and decreased vascular density in tumors than wild-type mice