Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr-HRAS)60Lc
• Allele Name: transgene insertion 60, Lynda Chin
• Allele ID: MGI:2676096
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp X/Tg(Tyr-HRAS)60Lc	involves: 129/Sv * C57BL/6J * CBA/J * SJL	MGI:4835048
cx2	Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh X/Tg(Tyr-HRAS)60Lc	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB	MGI:2676099
cx3	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp X/Tg(Tyr-HRAS)60Lc	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB	MGI:2676124
cx4	Cdkn2a^tm1Rdp/Cdkn2a^+ X/Tg(Tyr-HRAS)60Lc	involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL	MGI:3815142

Genotype
MGI:4835048

cn1

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:164588 )

♂ • mice are euthanized within 20 weeks due to tumor development

neoplasm

decreased tumor growth/size ( J:164588 )

♂ • tumor growth is less aggressive than in Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Tyr-cre/ERT2)13Bos mice

increased melanoma incidence ( J:164588 )

♂ • all mice develop melanomas within 20 weeks

Genotype
MGI:2676099

cx2

• Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

neoplasm

increased melanoma incidence ( J:85075 )

♂ • 40 week melanoma free survival as opposed to 89 weeks for wild-type mice

♂ • functioning of p16^INK4a was compromised in half of the tumors examined

Genotype
MGI:2676124

cx3

• Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

neoplasm

increased melanoma incidence ( J:85075 )

♂ • 75 week melanoma free survival as opposed to 89 weeks for wild-type mice

♂ • functioning of p19^ARF was compromised in more than half of the tumors examined

♂ • about 40% of tumors overexpressed p53 as demonstrated by Western blot analysis

Genotype
MGI:3815142

cx4

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL

neoplasm

increased intraocular melanoma incidence ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

increased incidence of tumors by UV-induction ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

vision/eye

increased intraocular melanoma incidence ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

cataract ( J:140820 )

♂ • following exposure to UVA and UVB, only one mouse developed cataracts unlike Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-HRAS)60Lc mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
uveal melanoma		DOID:6039	OMIM:155720 OMIM:606660 OMIM:606661	J:140820