Phenotypes associated with this allele

• Allele Symbol: Lgmn^tm1Ihn
• Allele Name: targeted mutation 1, Ikuko Hara-Nishimura
• Allele ID: MGI:2676125
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgmn^tm1Ihn/Lgmn^tm1Ihn	involves: 129P2/OlaHsd * C57BL/6	MGI:3836291
hm2	Lgmn^tm1Ihn/Lgmn^tm1Ihn	involves: 129P2/OlaHsd * C57BL/6J	MGI:2676138

Genotype
MGI:3836291

hm1

• Allelic Composition: Lgmn^tm1Ihn/Lgmn^tm1Ihn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hepatosplenomegaly in Lgmn^tm1Ihn/Lgmn^tm1Ihn mice

hematopoietic system

extramedullary hematopoiesis ( J:143886 )

• spleens exhibit an increase in the number of erythrocytes, immature myeloid lineage cells, and Ter-119+ erythroid lineage cells compared to in wild-type mice

• mice exhibit an increase in non-T and non-B cells in the spleen unlike in wild-type mice

anemia ( J:143886 )

abnormal bone marrow cell morphology/development ( J:143886 )

• mice exhibit hemophagocytes in the bone marrow in an age-dependent manner unlike in wild-type mice

abnormal erythrocyte morphology ( J:143886 )

• red blood cells exhibit defective plasma membrane components compared to in wild-type mice

decreased erythrocyte cell number ( J:143886 )

decreased hematocrit ( J:143886 )

• in an age-dependent manner

decreased hemoglobin content ( J:143886 )

decreased mean corpuscular hemoglobin ( J:143886 )

decreased mean corpuscular hemoglobin concentration ( J:143886 )

increased lymphocyte cell number ( J:143886 )

• in an age-dependent manner

reticulocytosis ( J:143886 )

• in an age-dependent manner

abnormal spleen morphology ( J:143886 )

• spleens are darker in color than in wild-type mice

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

abnormal NK cell physiology ( J:143886 )

• impaired

abnormal macrophage physiology ( J:143886 )

• red blood cell phagocytic activity of macrophages is increased compared to in wild-type mice

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:143886 )

increased body temperature ( J:143886 )

liver/biliary system

increased liver weight ( J:143886 )

immune system

immune system phenotype ( J:143886 )

N • despite increased body temperature, mice exhibit normal inflammatory cytokine levels

increased lymphocyte cell number ( J:143886 )

• in an age-dependent manner

abnormal spleen morphology ( J:143886 )

• spleens are darker in color than in wild-type mice

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

abnormal NK cell physiology ( J:143886 )

• impaired

abnormal macrophage physiology ( J:143886 )

• red blood cell phagocytic activity of macrophages is increased compared to in wild-type mice

increased circulating tumor necrosis factor level ( J:143886 )

growth/size/body

increased liver weight ( J:143886 )

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphatic system disease		DOID:75		J:143886

Genotype
MGI:2676138

hm2

• Allelic Composition: Lgmn^tm1Ihn/Lgmn^tm1Ihn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Enlargement of lysosomes in the kidney-proximal tubule cells of Lgmn^tm1Ihn/Lgmn^tm1Ihn mice

growth/size/body

decreased body weight ( J:85207 )

• observed after 20 weeks of age, with mean weights of 50-week old mutants about 80% of those of controls

slow postnatal weight gain ( J:85207 )

• initial weight gain is similar to controls, however 20 weeks after weaning, weight increase begins to stagnate and by 50 weeks, mutants weight is about 80% of controls

cellular

accumulation of giant lysosomes in kidney/renal tubule cells ( J:85207 )

• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age

renal/urinary system

accumulation of giant lysosomes in kidney/renal tubule cells ( J:85207 )

• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age