Phenotypes associated with this allele

• Allele Symbol: Cd83^tm1Tft
• Allele Name: targeted mutation 1, Thomas F Tedder
• Allele ID: MGI:2676282
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd83^tm1Tft/Cd83^tm1Tft	involves: 129S4/SvJae * C57BL/6	MGI:2676296

Genotype
MGI:2676296

hm1

• Allelic Composition: Cd83^tm1Tft/Cd83^tm1Tft
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:75700 )

• CD4+ single positive thymocyte maturation is blocked leading to defective CD4+ T cell generation

arrested T cell differentiation ( J:75700 )

• a block in CD4⁺ single-positive thymocyte development without increased CD8⁺ single- or CD4⁺/ CD8⁺ double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:75700 )

• a selective 75% to 90% reduction in peripheral CD4⁺ T cells, predominantly within the naive set

• numbers of naive CD44^lowCD4⁺ T cells in blood and spleen are reduced by 84-93%

decreased susceptibility to type IV hypersensitivity reaction ( J:75700 )

• mice show a 22% reduction in swelling of oxazolone-challenged ear, indicating impaired contact hypersensitivity responses, however the ability of DC to induce allogeneic T cell proliferation in vitro is normal

abnormal humoral immune response ( J:75700 )

• mutants have reduced humoral immune responses following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgA level ( J:75700 )

• decrease in IgA following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG1 level ( J:75700 )

• decrease in IgG1 following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG2a level ( J:75700 )

• decrease in IgG2a following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG2b level ( J:75700 )

• decrease in IgG2b following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG3 level ( J:75700 )

• decrease in IgG3 following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgM level ( J:75700 )

• decrease in IgM following challenge with a T cell-dependent antigen, DNP-KLH

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:75700 )

• CD4+ single positive thymocyte maturation is blocked leading to defective CD4+ T cell generation

arrested T cell differentiation ( J:75700 )

• a block in CD4⁺ single-positive thymocyte development without increased CD8⁺ single- or CD4⁺/ CD8⁺ double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:75700 )

• a selective 75% to 90% reduction in peripheral CD4⁺ T cells, predominantly within the naive set

• numbers of naive CD44^lowCD4⁺ T cells in blood and spleen are reduced by 84-93%

decreased IgA level ( J:75700 )

• decrease in IgA following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG1 level ( J:75700 )

• decrease in IgG1 following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG2a level ( J:75700 )

• decrease in IgG2a following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG2b level ( J:75700 )

• decrease in IgG2b following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgG3 level ( J:75700 )

• decrease in IgG3 following challenge with a T cell-dependent antigen, DNP-KLH

decreased IgM level ( J:75700 )

• decrease in IgM following challenge with a T cell-dependent antigen, DNP-KLH