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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja1tm5(cre/ERT)Kwi
targeted mutation 5, Klaus Willecke
MGI:2676327
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi involves: 129P2/OlaHsd MGI:3720020
cn2
 		Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi involves: 129P2/OlaHsd * C57BL/6 MGI:3720023


Genotype
MGI:3720020
cn1
Allelic
Composition		 Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1Kwi mutation (1 available); any Gja1 mutation (59 available)
Gja1tm5(cre/ERT)Kwi mutation (1 available); any Gja1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
irregular heartbeat ( J:102342 )
• ectopic ventricular beats and ventricle tachycardia are observed in 7 of 10 4-OHT treated mice
abnormal impulse conducting system conduction ( J:102342 )
• 4-OHT treated mice have impaired conduction that is more pronounced on the right ventricle than the left ventricle
• longitudinal and transverse conduction is reduced on the right ventricle in 4-OHT treated mice
• transverse conduction is reduced on the left ventricle in 4-OHT treated mice

immune system
abnormal neutrophil physiology ( J:129091 )
• following treatment with tamoxifen, ATP release from polymorphonuclear (PMN) cells is less than 15% of wild-type

hematopoietic system
abnormal neutrophil physiology ( J:129091 )
• following treatment with tamoxifen, ATP release from polymorphonuclear (PMN) cells is less than 15% of wild-type




Genotype
MGI:3720023
cn2
Allelic
Composition		 Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm1Kwi mutation (1 available); any Gja1 mutation (59 available)
Gja1tm5(cre/ERT)Kwi mutation (1 available); any Gja1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired skin barrier function ( J:85065 )
• 4-OHT treated mice exhibit 40% reduction in coupling compared to un-induced and wild-type mice

integument
impaired skin barrier function ( J:85065 )
• 4-OHT treated mice exhibit 40% reduction in coupling compared to un-induced and wild-type mice




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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory