Phenotypes associated with this allele

• Allele Symbol: Gja1^{tm5(cre/ERT)Kwi}
• Allele Name: targeted mutation 5, Klaus Willecke
• Allele ID: MGI:2676327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gja1^tm1Kwi/Gja1^tm5(cre/ERT)Kwi	involves: 129P2/OlaHsd	MGI:3720020
cn2	Gja1^tm1Kwi/Gja1^tm5(cre/ERT)Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3720023

Genotype
MGI:3720020

cn1

• Allelic Composition: Gja1^tm1Kwi/Gja1^{tm5(cre/ERT)Kwi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart rate ( J:102342 )

irregular heartbeat ( J:102342 )

• ectopic ventricular beats and ventricle tachycardia are observed in 7 of 10 4-OHT treated mice

abnormal impulse conducting system conduction ( J:102342 )

• 4-OHT treated mice have impaired conduction that is more pronounced on the right ventricle than the left ventricle

• longitudinal and transverse conduction is reduced on the right ventricle in 4-OHT treated mice

• transverse conduction is reduced on the left ventricle in 4-OHT treated mice

immune system

abnormal neutrophil physiology ( J:129091 )

• following treatment with tamoxifen, ATP release from polymorphonuclear (PMN) cells is less than 15% of wild-type

hematopoietic system

abnormal neutrophil physiology ( J:129091 )

• following treatment with tamoxifen, ATP release from polymorphonuclear (PMN) cells is less than 15% of wild-type

Genotype
MGI:3720023

cn2

• Allelic Composition: Gja1^tm1Kwi/Gja1^{tm5(cre/ERT)Kwi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

impaired skin barrier function ( J:85065 )

• 4-OHT treated mice exhibit 40% reduction in coupling compared to un-induced and wild-type mice

integument

impaired skin barrier function ( J:85065 )

• 4-OHT treated mice exhibit 40% reduction in coupling compared to un-induced and wild-type mice