Phenotypes associated with this allele

• Allele Symbol: Stk11^tm1.1Jish
• Allele Name: targeted mutation 1.1, Kou-ichi Jishage
• Allele ID: MGI:2676546
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk11^tm1.1Jish/Stk11^tm1.1Jish	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2676548
ht2	Stk11^tm1.1Jish/Stk11^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2676549

Genotype
MGI:2676548

hm1

• Allelic Composition: Stk11^tm1.1Jish/Stk11^tm1.1Jish
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation, impaired embryo turning and small somites in Stk11^tm1.1Jish/Stk11^tm1.1Jish embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77213 )

• death between E8.5 and E9.5

embryo

incomplete embryo turning ( J:77213 )

• embryos did not undergo embryonic turning

embryonic growth retardation ( J:77213 )

• embryos at E9 form only 10 pairs of somites and resemble E8-8.5 wild-type embryos

decreased embryo size ( J:77213 )

• smaller than wild-type at E9 and showed developmental retardation

decreased somite size ( J:77213 )

• somites at E9 are smaller than in equivalent sized (E8.5) wild-type embryos

growth/size/body

embryonic growth retardation ( J:77213 )

• embryos at E9 form only 10 pairs of somites and resemble E8-8.5 wild-type embryos

decreased embryo size ( J:77213 )

• smaller than wild-type at E9 and showed developmental retardation

Genotype
MGI:2676549

ht2

• Allelic Composition: Stk11^tm1.1Jish/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Stk11^tm1.1Jish/Stk11⁺ mice develop gastrointestinal polyps

neoplasm

increased adenoma incidence ( J:77213 )

• all mice showed gastric adenomatous polyps at 10 and 14 months of age, predominantly in the glandular stomach

increased intestinal adenoma incidence ( J:77213 )

digestive/alimentary system

increased intestinal adenoma incidence ( J:77213 )

gastric polyps ( J:77213 )

• mutants develop polyps by 10 months of age; most polyps localize at the junction of pyloric antrum and duodenum in the glandular stomach

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:77213