Phenotypes associated with this allele

• Allele Symbol: Kcnj9^tm1Kwn
• Allele Name: targeted mutation 1, Kevin Wickman
• Allele ID: MGI:2676585
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnj9^tm1Kwn/Kcnj9^tm1Kwn	involves: 129X1/SvJ	MGI:2676599
cx2	Kcnj6^tm1Stf/Kcnj6^tm1Stf Kcnj9^tm1Kwn/Kcnj9^tm1Kwn	involves: 129S1/Sv * 129X1/SvJ	MGI:2676603

Genotype
MGI:2676599

hm1

• Allelic Composition: Kcnj9^tm1Kwn/Kcnj9^tm1Kwn
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic transmission ( J:77047 )

• resting membrane potentials of locus ceruleus neurons in brain slices are depolarized by 15-20 mV relative to neurons from wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:77047 )

N • mice are fertile and of normal size, exhibit normal coordination and show no abnormal feeding behavior, grooming, or responses to visual or auditory cues

N • no observed propensity for spontaneous and lethal seizures

Genotype
MGI:2676603

cx2

• Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf; Kcnj9^tm1Kwn/Kcnj9^tm1Kwn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:77047 )

• between 2 and 8 months due to spontaneous seizures

behavior/neurological

seizures ( J:77047 )

• spontaneous lethal seizures between 2 and 8 months of age

nervous system

seizures ( J:77047 )

• spontaneous lethal seizures between 2 and 8 months of age

abnormal synaptic transmission ( J:77047 )

• resting membrane potentials of locus ceruleus neurons in brain slices are depolarized by 15-20 mV realative to neurons from wild-type mice

• opioid ([Met]⁵ enkephalin)-induced hyperpolarization and whole-cell current is reduced by 80% in locus ceruleus neurons

• the small opioid-sensitive current that is observed in locus ceruleus neurons is eliminated with the nonselective potassium channel blockers barium and cesium