Phenotypes associated with this allele

• Allele Symbol: Pde1b^tm1Cvv
• Allele Name: targeted mutation 1, Charles V Vorhees
• Allele ID: MGI:2676625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde1b^tm1Cvv/Pde1b^tm1Cvv	involves: 129P2/OlaHsd * C57BL/6	MGI:2676629

Genotype
MGI:2676629

hm1

• Allelic Composition: Pde1b^tm1Cvv/Pde1b^tm1Cvv
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased exploration in new environment ( J:77514 )

• especially in the first 30 minutes then habituating toward wild-type levels although always greater than wild-type

abnormal spatial learning ( J:77514 )

• in a morris maze test, homozygous mice follow longer paths and the cumulative distance from the target also greater

• longer latencies on day 3 of testing

• homozygotes show less improvement in performance from day to day than controls

hyperactivity ( J:77514 )

• more hyperactive after D-methamphetamine stimulation

• both overall activity and rate of change are increased

• females tended to be more active even before stimulation than were males when compared to wild-type mice