hearing/vestibular/ear
• slight at 9 weeks
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• at 2 weeks
• however, mice exhibit normal outer hair cell proliferation
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• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
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• very severe in small patches
• inner hair cells, outer hair cells and pillar cells are replaced with rosette-like formation composed of Claudius and Hensen cells at 9 weeks
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• at 2, 4 and 9 weeks of age
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nervous system
• slight at 9 weeks
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• at 2 weeks
• however, mice exhibit normal outer hair cell proliferation
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• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
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